(Q39013667)

8 September 2017

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title

Non-Smad Signaling Pathways of the TGF-β Family (English)

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8 September 2017

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27864313%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Ying E Zhang

series ordinal

1

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8 September 2017

18 November 2016

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Cold Spring Harbor Perspectives in Biology

8 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27864313%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27864313%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27864313%20AND%20SRC:MED&resulttype=core&format=json

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

5 June 2020

cites work

1 reference

12 December 2020

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

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12 December 2020

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

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12 December 2020

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

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12 December 2020

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

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12 December 2020

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

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12 December 2020

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

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12 December 2020

Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter

1 reference

12 December 2020

BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6

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12 December 2020

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis

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12 December 2020

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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12 December 2020

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

1 reference

12 December 2020

Cell signaling by receptor tyrosine kinases

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12 December 2020

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

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12 December 2020

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

12 December 2020

Cross-talk between IL-6 and TGF-beta signaling in hepatoma cells

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12 December 2020

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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12 December 2020

The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation

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12 December 2020

Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells

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12 December 2020

Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

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12 December 2020

Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells

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12 December 2020

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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12 December 2020

Evidence for a role of the JNK cascade in Smad7-mediated apoptosis

1 reference

12 December 2020

Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity.

1 reference

12 December 2020

Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling

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12 December 2020

Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity

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12 December 2020

Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

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12 December 2020

Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7

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12 December 2020

TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

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12 December 2020

Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells

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12 December 2020

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

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12 December 2020

Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes

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12 December 2020

Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.

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12 December 2020

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

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12 December 2020

p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.

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12 December 2020

Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase

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12 December 2020

TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2

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12 December 2020

Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

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12 December 2020

Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.

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12 December 2020

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

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12 December 2020

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

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12 December 2020

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

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12 December 2020

Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3

1 reference

12 December 2020

Membrane rafts play a crucial role in receptor activator of nuclear factor kappaB signaling and osteoclast function

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12 December 2020

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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12 December 2020

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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12 December 2020

Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation

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12 December 2020

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

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12 December 2020

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

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12 December 2020

Lipid rafts are important for the association of RANK and TRAF6

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12 December 2020

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.

1 reference

12 December 2020

Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

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12 December 2020

A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A

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12 December 2020

PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

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12 December 2020

Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells

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12 December 2020

Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42.

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12 December 2020

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

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12 December 2020

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

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12 December 2020

TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells

1 reference

12 December 2020

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

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12 December 2020

Activation of p21ras by transforming growth factor beta in epithelial cells

1 reference

12 December 2020

Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis

1 reference

12 December 2020

Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis

1 reference

12 December 2020

Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro

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12 December 2020

Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo

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12 December 2020

Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.

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12 December 2020

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

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12 December 2020

High-throughput mapping of a dynamic signaling network in mammalian cells

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12 December 2020

Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension

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12 December 2020

Non-Smad TGF-beta signals

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12 December 2020

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.

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12 December 2020

Ubiquitylation and cell signaling

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12 December 2020

Rho GTPases: biochemistry and biology

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12 December 2020

Specificity and versatility in tgf-beta signaling through Smads

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12 December 2020

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

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12 December 2020

Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

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12 December 2020

Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation

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12 December 2020

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

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12 December 2020

The TGF beta activated kinase TAK1 regulates vascular development in vivo

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12 December 2020

Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2.

1 reference

12 December 2020

A FoxO-Smad synexpression group in human keratinocytes

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12 December 2020

Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling

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12 December 2020

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

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12 December 2020

The JNK signal transduction pathway

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12 December 2020

Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion

1 reference

12 December 2020

Integrating signals from RTKs to ERK/MAPK.

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12 December 2020

Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition

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12 December 2020

Characteristics and biological functions of TRAF6

1 reference

12 December 2020

Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

1 reference

12 December 2020

TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

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12 December 2020

ERK signaling is a central regulator for BMP-4 dependent capillary sprouting

1 reference

12 December 2020

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

1 reference

12 December 2020

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling

1 reference

12 December 2020

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

1 reference

12 December 2020

TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.

1 reference

12 December 2020

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

1 reference

12 December 2020

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

1 reference

12 December 2020

BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity.

1 reference

12 December 2020

Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity

1 reference

12 December 2020

Non-Smad pathways in TGF-beta signaling

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12 December 2020

Tgf-beta superfamily signaling in embryonic development and homeostasis

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12 December 2020

BMP-2 signaling in ovarian cancer and its association with poor prognosis.

1 reference

12 December 2020

TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

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12 December 2020

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

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12 December 2020

Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane

1 reference

12 December 2020

BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation

1 reference

12 December 2020

Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation

1 reference

12 December 2020

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.

1 reference

12 December 2020

TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression

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12 December 2020

Identification of an mRNP complex regulating tumorigenesis at the translational elongation step

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12 December 2020

Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression

1 reference

12 December 2020

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.

1 reference

12 December 2020

Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway

1 reference

12 December 2020

PI3K, Erk signaling in BMP7-induced epithelial-mesenchymal transition (EMT) of PC-3 prostate cancer cells in 2- and 3-dimensional cultures

1 reference

12 December 2020

Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension

1 reference

12 December 2020

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.

1 reference

12 December 2020

BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells

1 reference

12 December 2020

TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

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12 December 2020

Induction of epithelial-mesenchymal transition by transforming growth factor β.

1 reference

12 December 2020

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis.

1 reference

12 December 2020

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

1 reference

12 December 2020

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

1 reference

12 December 2020

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

1 reference

12 December 2020

TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion

1 reference

12 December 2020

TGFβ signalling in context

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12 December 2020

TGF-β signaling and epithelial-mesenchymal transition in cancer progression

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12 December 2020

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

1 reference

12 December 2020

The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.

1 reference

12 December 2020

TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis

1 reference

12 December 2020

Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation

1 reference

12 December 2020

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6.

1 reference

12 December 2020

TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1.

1 reference

12 December 2020

PI3K and cancer: lessons, challenges and opportunities

1 reference

12 December 2020

Molecular mechanisms of epithelial-mesenchymal transition

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12 December 2020

Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β

1 reference

12 December 2020

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

1 reference

12 December 2020

ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation

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12 December 2020

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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12 December 2020

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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12 December 2020

Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells.

1 reference

12 December 2020

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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12 December 2020

Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

1 reference

12 December 2020

Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells.

1 reference

12 December 2020

The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues

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12 December 2020

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

12 December 2020

Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

1 reference

12 December 2020

Transforming growth factor-beta1 stimulates protein kinase A in mesangial cells

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12 December 2020

TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes

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12 December 2020

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

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12 December 2020

Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

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12 December 2020

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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12 December 2020

10.1101/CSHPERSPECT.A022129

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27864313%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27864313%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference