(Q39084230)

8 September 2017

title

A high-yielding CHO transient system: coexpression of genes encoding EBNA-1 and GS enhances transient protein expression (English)

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8 September 2017

Olalekan Daramola

1

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8 September 2017

Jessica Stevenson

2

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8 September 2017

Greg Dean

3

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8 September 2017

Diane Hatton

4

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8 September 2017

Gary Pettman

5

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8 September 2017

William Holmes

6

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8 September 2017

Ray Field

7

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8 September 2017

publication date

10 October 2013

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8 September 2017

published in

Biotechnology Progress

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8 September 2017

volume

30

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8 September 2017

issue

1

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8 September 2017

page(s)

132-141

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Recombinant therapeutic protein production in cultivated mammalian cells: current status and future prospects

8 September 2017

cites work

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Production of recombinant protein therapeutics in cultivated mammalian cells

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Mammalian cell protein expression for biopharmaceutical production

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Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

21 January 2018

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CHO cells in biotechnology for production of recombinant proteins: current state and further potential

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Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

21 January 2018

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Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives

21 January 2018

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Reflections on more than 10 years of TGE approaches

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Transient recombinant protein expression in a human amniocyte cell line: the CAP-T® cell system

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Expression systems for therapeutic glycoprotein production.

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Large-scale transfection of mammalian cells for the fast production of recombinant protein

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Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions

21 January 2018

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Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells

21 January 2018

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Purification of the extracellular domain of the membrane protein GlialCAM expressed in HEK and CHO cells and comparison of the glycosylation

21 January 2018

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Erythropoietin produced in a human cell line (Dynepo) has significant differences in glycosylation compared with erythropoietins produced in CHO cell lines

21 January 2018

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Transient expression of an IL-23R extracellular domain Fc fusion protein in CHO vs. HEK cells results in improved plasma exposure.

21 January 2018

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Cell type-specific and site directed N-glycosylation pattern of FcγRIIIa.

21 January 2018

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Serum-free large-scale transient transfection of CHO cells

21 January 2018

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Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non-instrumented cultivation systems

21 January 2018

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Transient transfection factors for high-level recombinant protein production in suspension cultured mammalian cells

21 January 2018

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High-level protein expression in scalable CHO transient transfection

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Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells.

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Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells

21 January 2018

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A simple high-yielding process for transient gene expression in CHO cells.

21 January 2018

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A CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expression

21 January 2018

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The CELO adenovirus Gam1 protein enhances transient and stable recombinant protein expression in Chinese hamster ovary cells.

21 January 2018

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Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-x(L).

21 January 2018

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Epi-CHO, an episomal expression system for recombinant protein production in CHO cells

21 January 2018

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Glutamine synthetase in brain: effect of ammonia

21 January 2018

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An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries

21 January 2018

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Long-term replication of Epstein-Barr virus-derived episomal vectors in the rodent cells

21 January 2018

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trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.

21 January 2018

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Transient transfection of CHO-K1-S using serum-free medium in suspension: a rapid mammalian protein expression system

21 January 2018

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Enhanced CHO cell-based transient gene expression with the epi-CHO expression system

21 January 2018

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The heterogeneous nature of polyethylenimine-DNA complex formation affects transient gene expression

21 January 2018

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Iron (III) citrate inhibits polyethylenimine-mediated transient transfection of Chinese hamster ovary cells in serum-free medium

21 January 2018

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Cell line specific control of polyethylenimine-mediated transient transfection optimized with "Design of experiments" methodology

21 January 2018

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N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG.

21 January 2018

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Optimal and consistent protein glycosylation in mammalian cell culture

21 January 2018

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Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

21 January 2018

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Industry and regulatory experience of the glycosylation of monoclonal antibodies

21 January 2018

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Glycosylation profiles of therapeutic antibody pharmaceuticals.

21 January 2018

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Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells.

21 January 2018

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Pleiotrophic functions of Epstein-Barr virus nuclear antigen-1 (EBNA-1) and oriP differentially contribute to the efficiency of transfection/expression of exogenous gene in mammalian cells

21 January 2018

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Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival

21 January 2018

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Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death

21 January 2018

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Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells

21 January 2018

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Differences in human cell lines to support stable replication of Epstein-Barr virus-based vectors.

21 January 2018

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Epstein-Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processing

21 January 2018

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About making a CHO production cell line "research-friendly" by genetic engineering

21 January 2018

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Epstein-Barr virus promotes genomic instability in Burkitt's lymphoma

21 January 2018

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The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.

21 January 2018

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The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress

21 January 2018

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Glutamine homeostasis and mitochondrial dynamics

21 January 2018

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Valproic acid: a viable alternative to sodium butyrate for enhancing protein expression in mammalian cell cultures

21 January 2018

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Coexpression of acidic fibroblast growth factor enhances specific productivity and antibody titers in transiently transfected HEK293 cells

21 January 2018

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The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

21 January 2018

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Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BTPR.1809

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8 September 2017

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