(Q39205354)

English

Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification

scientific article published on 4 February 2013

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scholarly article

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Europe PubMed Central

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22 February 2020

Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification (English)

1 reference

Europe PubMed Central

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22 February 2020

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1

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22 February 2020

author name string

Yasuhiro Tsume

2

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22 February 2020

Gordon L Amidon

3

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22 February 2020

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4 February 2013

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22 February 2020

Molecular Pharmaceutics

1 reference

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22 February 2020

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22 February 2020

3

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22 February 2020

958-966

1 reference

Europe PubMed Central

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22 February 2020

Role of the equilibrative and concentrative nucleoside transporters in the intestinal absorption of the nucleoside drug, ribavirin, in wild-type and Ent1(-/-) mice.

1 reference

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10 September 2017

Drug-permeability and transporter assays in Caco-2 and MDCK cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice

1 reference

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10 September 2017

Summary workshop report: bioequivalence, biopharmaceutics classification system, and beyond

1 reference

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10 September 2017

Application of the biopharmaceutical classification system in clinical drug development--an industrial view

1 reference

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10 September 2017

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

1 reference

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10 September 2017

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

Comparison between permeability coefficients in rat and human jejunum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

Stepwise determination of multicompartment disposition and absorption parameters from extravascular concentration-time data. Application to mesoridazine, flurbiprofen, flunarizine, labetalol, and diazepam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

Pharmacokinetics and pharmacodynamic studies of labetalol in hypertensive subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

10 September 2017

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

14 September 2017

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

14 September 2017

Biopharmaceutics classification of selected beta-blockers: solubility and permeability class membership

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

14 September 2017

Use of the Biopharmaceutical Classification System in early drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

15 June 2018

Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

15 June 2018

Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

15 June 2018

Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

15 June 2018

Metabolism of labetalol by animals and man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

15 June 2018

Single-pass intestinal perfusion to establish the intestinal permeability of model drugs in mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

Fast log P determination by ultra-high-pressure liquid chromatography coupled with UV and mass spectrometry detections

1 reference

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21 August 2018

Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

Profile of P-glycoprotein distribution in the rat and its possible influence on the salbutamol intestinal absorption process.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

21 August 2018

High-permeability criterion for BCS classification: segmental/pH dependent permeability considerations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605724

4 November 2018

Measurement of dissociation constants (pKa values) of organic compounds by multiplexed capillary electrophoresis using aqueous and cosolvent buffers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of dilevalol (I). Comparison of the pharmacokinetic and pharmacodynamic properties of dilevalol and labetalol after a single oral administration in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BCS, BDDCS, and regulatory guidances

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The suitability of an in situ perfusion model for permeability determinations: utility for BCS class I biowaiver requests

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of the pKa values of β-blockers by automated potentiometric titrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic comparison of pindolol with other beta-adrenoceptor-blocking agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Labetalol absorption kinetics: rat small intestine and colon studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23327720

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/MP300410N

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23327720%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23327720%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23327720%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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