(Q39205763)

English

Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements

scientific article published on 24 January 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

10 September 2017

Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements (English)

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Caroline A Larregieu

1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Leslie Z Benet

2

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Europe PubMed Central

PMC publication ID

10 September 2017

language of work or name

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publication date

24 January 2013

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Europe PubMed Central

PMC publication ID

10 September 2017

The AAPS Journal

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Europe PubMed Central

PMC publication ID

10 September 2017

15

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

483-497

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development

1 reference

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10 September 2017

BDDCS applied to over 900 drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Coexistence of passive and carrier-mediated processes in drug transport

1 reference

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10 September 2017

The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted

1 reference

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10 September 2017

Membrane transporters in drug development

1 reference

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10 September 2017

Permeability for intestinal absorption: Caco-2 assay and related issues

1 reference

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10 September 2017

High-affinity interaction of sartans with H+/peptide transporters

1 reference

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10 September 2017

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

1 reference

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10 September 2017

Simulation modelling of human intestinal absorption using Caco-2 permeability and kinetic solubility data for early drug discovery

1 reference

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10 September 2017

Intestinal permeability and its relevance for absorption and elimination

1 reference

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10 September 2017

Estimation of ADME properties in drug discovery: predicting Caco-2 cell permeability using atom-based stochastic and non-stochastic linear indices

1 reference

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10 September 2017

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting

1 reference

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10 September 2017

Variability in Caco-2 and MDCK cell-based intestinal permeability assays

1 reference

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10 September 2017

Predicting Caco-2 permeability using support vector machine and chemistry development kit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Structure and function of the intercellular junctions: barrier of paracellular drug delivery

1 reference

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10 September 2017

Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies

1 reference

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10 September 2017

Transporter-mediated Drug Interactions

1 reference

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10 September 2017

Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin

1 reference

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10 September 2017

The concentrative nucleoside transporter family, SLC28

1 reference

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10 September 2017

Pulmonary absorption rate and bioavailability of drugs in vivo in rats: structure-absorption relationships and physicochemical profiling of inhaled drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Targeted prodrug design to optimize drug delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Theoretical calculation and prediction of drug transport processes using simple parameters and partial least squares projections to latent structures (PLS) statistics. The use of electrotopological state indices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Caco-2 monolayers in experimental and theoretical predictions of drug transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Prediction of polar surface area and drug transport processes using simple parameters and PLS statistics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Enhancing the hit-to-lead properties of lead optimization libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Serum and cerebrospinal fluid pharmacokinetics of intravenous and oral lamivudine in human immunodeficiency virus-infected children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Comparison between permeability coefficients in rat and human jejunum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

10 September 2017

The application of molecular structural predictors of intestinal absorption to screening of compounds for transdermal penetration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

In silico prediction of human oral absorption based on QSAR analyses of PAMPA permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Biopharmaceutics classification of selected beta-blockers: solubility and permeability class membership

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

In silico prediction of membrane permeability from calculated molecular parameters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Exploring the role of different drug transport routes in permeability screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Biopharmaceutical characterization of sotalol-containing oral immediate release drug products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Predicting Caco-2 cell permeation coefficients of organic molecules using membrane-interaction QSAR analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Absorption of ofloxacin isomers in the rat small intestine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

14 September 2017

Experimental and computational screening models for the prediction of intestinal drug absorption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

25 September 2017

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

25 September 2017

Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

25 September 2017

Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

25 September 2017

Prodrugs revisited: the "ad hoc" approach as a complement to ligand design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

25 September 2017

Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

25 September 2017

Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

25 September 2017

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Development and evaluation of an in vitro method for prediction of human drug absorption II. Demonstration of the method suitability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Caco-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Evaluation of an accelerated Caco-2 cell permeability model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Regulation of the movement of solutes across tight junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Human intestinal permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

15 June 2018

Caco-2 replace or refine?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Do the recommended standards for in vitro biopharmaceutic classification of drug permeability meet the "passive transport" criterion for biowaivers?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Prediction of the in vitro permeability determined in Caco-2 cells by using artificial neural networks.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Towards prediction of in vivo intestinal absorption using a 96-well Caco-2 assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

The use of drug metabolism for prediction of intestinal permeability (dagger).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Passive oral drug absorption can be predicted more reliably by experimental than computational models--fact or myth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Caco-2 cell permeability modelling: a neural network coupled genetic algorithm approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration.

1 reference

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21 August 2018

Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Prediction of the permeability of drugs through study on quantitative structure-permeability relationship.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification

1 reference

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21 August 2018

Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

ADME evaluation in drug discovery. 5. Correlation of Caco-2 permeation with simple molecular properties.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Interactions of human organic anion transporters with diuretics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Predicting oral absorption of drugs: a case study with a novel class of antimicrobial agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Optimizing Caco-2 cell monolayers to increase throughput in drug intestinal absorption analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Prediction of Caco-2 cell permeability using a combination of MO-calculation and neural network.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Human organic anion transporters and human organic cation transporters mediate renal antiviral transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

A comprehensive account on the role of efflux transporters in the gastrointestinal absorption of 13 commonly used substrate drugs in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Prediction of drug transport processes using simple parameters and PLS statistics. The use of ACD/logP and ACD/ChemSketch descriptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Strategies toward predicting peptide cellular permeability from computed molecular descriptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3675726

21 August 2018

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption classification of oral drugs based on molecular surface properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VolSurf: a new tool for the pharmacokinetic optimization of lead compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative structure/property relationship analysis of Caco-2 permeability using a genetic algorithm-based partial least squares method

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BCS, BDDCS, and regulatory guidances

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting drug absorption from molecular surface properties based on molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro permeability of eight beta-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of in vitro and in vivo models for the oral absorption of peptide drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new topological descriptors based model for predicting intestinal epithelial transport of drugs in Caco-2 cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of drug absorption with molecular surface properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of pregabalin in rat intestine and Caco-2 monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of oral drug absorption in humans--from cultured cell lines and experimental animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Caco-2 cell monolayer: usefulness and limitations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of drug permeation across Caco-2 monolayer: implication for predicting in vivo drug absorption.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of simulated intestinal fluid for Caco-2 permeability assay of lipophilic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of in vitro pharmacokinetic screens using Caco-2, human hepatocyte, and Caco-2/human hepatocyte hybrid systems for the prediction of oral bioavailability in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23344793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1208/S12248-013-9456-8

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Sitelinks

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