(Q39297991)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

5

1 reference

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11 February 2020

Ryan F.L. O'Shaughnessy

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

author name string

K Sully

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

O Akinduro

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

M P Philpott

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

A S Naeem

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

V E Reeve

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

C Byrne

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

language of work or name

English

0 references

publication date

13 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

issue

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

page(s)

3254-3262

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2012.338

11 February 2020

exact match

0 references

cites work

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1 reference

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Lower malignancy rates in renal allograft recipients converted to sirolimus-based, calcineurin inhibitor-free immunotherapy: 24-month results from the CONVERT trial

21 January 2018

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Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial

21 January 2018

1 reference

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Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A.

21 January 2018

1 reference

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

1 reference

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Transplantation: can sirolimus prevent skin cancer in transplant recipients?

21 January 2018

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Functional roles of Akt signaling in mouse skin tumorigenesis.

21 January 2018

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Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression

21 January 2018

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Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.

21 January 2018

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AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes

21 January 2018

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AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation

21 January 2018

1 reference

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Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors

21 January 2018

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Role of translocation in the activation and function of protein kinase B

21 January 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Class I PI3K in oncogenic cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

The Growth and Differentiation of Cultured Newborn Rat Keratinocytes

21 January 2018

1 reference

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Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.

21 January 2018

1 reference

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Restraining PI3K: mTOR signalling goes back to the membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Rapamycin partially prevents insulin resistance induced by chronic insulin treatment

21 January 2018

1 reference

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Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

21 January 2018

1 reference

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Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

21 January 2018

1 reference

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Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Phosphorylation of IRS proteins, insulin action, and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

21 January 2018

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Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.338

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

The Akt kinases: isoform specificity in metabolism and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

The regulation of skin proliferation and differentiation in the IR null mouse: implications for skin complications of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

UVB-induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Stratum corneum lipid abnormalities in atopic dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Parameters of protection against ultraviolet radiation-induced skin cell damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

Radiation sources providing increased UVA/UVB ratios induce photoprotection dependent on the UVA dose in hairless mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.338

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.338

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22890326%20AND%20SRC:MED&resulttype=core&format=json

release_n4mdgalaijbavja3qxzyttsva4

11 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/n4mdgalaijbavja3qxzyttsva4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference