(Q39333779)

11 September 2017

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title

Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy (English)

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11 September 2017

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Hadas Han

1

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11 September 2017

Aniv Mann

series ordinal

2

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11 September 2017

Dana Ekstein

series ordinal

3

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11 September 2017

Sara Eyal

series ordinal

4

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11 September 2017

language of work or name

English

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publication date

26 May 2017

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11 September 2017

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11 September 2017

19

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11 September 2017

4

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11 September 2017

973-988

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https://scigraph.springernature.com/pub.10.1208/s12248-017-0096-2

11 September 2017

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Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy

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Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy

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Involvement of microRNAs in epileptogenesis

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Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

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12 December 2020

Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis

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Effects on EEG of the osmotic opening of the blood-brain barrier in rats.

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Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent.

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Blood-brain barrier dysfunction, seizures and epilepsy

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Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)

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Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier.

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12 December 2020

1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy

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12 December 2020

Multimodality imaging of blood-brain barrier impairment during epileptogenesis.

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12 December 2020

Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy

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12 December 2020

P-glycoprotein expression and antiepileptic drug resistance

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12 December 2020

Molecular cascades that mediate the influence of inflammation on epilepsy

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12 December 2020

The role of inflammation in epilepsy

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12 December 2020

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

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12 December 2020

Drug interactions at the blood-brain barrier: fact or fantasy?

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Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury

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Drug-resistant epilepsy

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The multidrug transporter P-glycoprotein in pharmacoresistance to antiepileptic drugs

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12 December 2020

Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?

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Phenotypic spectrum of glucose transporter type 1 deficiency syndrome (Glut1 DS).

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White matter angiopathy is common in pediatric patients with intractable focal epilepsies

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12 December 2020

Decrease in dystrophin expression prior to disruption of brain-blood barrier within the rat piriform cortex following status epilepticus

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12 December 2020

Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy

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12 December 2020

Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.

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Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning.

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Localization and characterization of cytochrome P450 in the brain. In vivo and in vitro investigations on phenytoin- and phenobarbital-inducible isoforms

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Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter.

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Imaging transporters: Transforming diagnostic and therapeutic development

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12 December 2020

The transport of antiepileptic drugs by P-glycoprotein

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12 December 2020

Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro

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12 December 2020

Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs

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12 December 2020

A pilot double-blind trial using verapamil as adjuvant therapy for refractory seizures

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12 December 2020

Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics

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12 December 2020

Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions

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12 December 2020

Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis

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12 December 2020

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

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12 December 2020

Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus

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12 December 2020

Potential role of drug transporters in the pathogenesis of medically intractable epilepsy

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12 December 2020

Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[11C]verapamil PET study.

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12 December 2020

Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier

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12 December 2020

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

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12 December 2020

Advances in the development of biomarkers for epilepsy.

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12 December 2020

Cerebral expression of drug transporters in epilepsy

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12 December 2020

Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy

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12 December 2020

Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.

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12 December 2020

Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays.

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12 December 2020

Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine

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12 December 2020

The role of brain edema in epileptic brain damage induced by systemic kainic acid injection.

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12 December 2020

Advances of Molecular Imaging in Epilepsy

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12 December 2020

Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside

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12 December 2020

Intrinsic severity as a determinant of antiepileptic drug refractoriness

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12 December 2020

Tracking inflammation in the epileptic rat brain by bi-functional fluorescent and magnetic nanoparticles.

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12 December 2020

Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice

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12 December 2020

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study.

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12 December 2020

Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling

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12 December 2020

Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches

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12 December 2020

The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2).

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12 December 2020

Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography

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12 December 2020

Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?

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12 December 2020

Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes

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12 December 2020

Low dose verapamil as an adjunct therapy for medically refractory epilepsy - An open label pilot study.

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12 December 2020

Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow

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12 December 2020

Seizure-promoting effect of blood-brain barrier disruption

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12 December 2020

Presence of claudins mRNA in the brain. Selective modulation of expression by kindling epilepsy.

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12 December 2020

Increased perivascular laminin predicts damage to astrocytes in CA3 and piriform cortex following chemoconvulsive treatments.

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12 December 2020

Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.

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12 December 2020

The UCSF-FDA TransPortal: a public drug transporter database

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12 December 2020

Transport of valproate at intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells: mechanism and substrate specificity

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12 December 2020

Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.

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12 December 2020

Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

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12 December 2020

The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver

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12 December 2020

Regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by various convulsive agents

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12 December 2020

MMP-9 in translation: from molecule to brain physiology, pathology, and therapy

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12 December 2020

Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.

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12 December 2020

Blood-brain barrier, epileptogenesis, and treatment strategies in cortical dysplasia

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12 December 2020

Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation

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12 December 2020

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

1 reference

12 December 2020

Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells.

1 reference

12 December 2020

Drug resistance in brain diseases and the role of drug efflux transporters.

1 reference

12 December 2020

WONOEP appraisal: Molecular and cellular biomarkers for epilepsy

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12 December 2020

Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement

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12 December 2020

Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant- and prepubertal rats after pentylenetetrazole-induced seizure.

1 reference

12 December 2020

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

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12 December 2020

In vivo and in vitro effects of pilocarpine: relevance to ictogenesis.

1 reference

12 December 2020

Glia and epilepsy: excitability and inflammation

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12 December 2020

Candidate drug targets for prevention or modification of epilepsy

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12 December 2020

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

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12 December 2020

Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

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12 December 2020

Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain

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12 December 2020

Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

1 reference

12 December 2020

Effects of levetiracetam on blood-brain barrier disturbances following hyperthermia-induced seizures in rats with cortical dysplasia.

1 reference

12 December 2020

Molecular Imaging of Membrane Transporters' Activity in Cancer: a Picture is Worth a Thousand Tubes

1 reference

12 December 2020

The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy.

1 reference

12 December 2020

A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels.

1 reference

12 December 2020

The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus

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12 December 2020

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

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12 December 2020

Dynamic contrast-enhanced MRI of Gd-albumin delivery to the rat hippocampus in vivo by convection-enhanced delivery.

1 reference

12 December 2020

Clinical Applications of Simultaneous PET/MR Imaging Using (R)-[11C]-Verapamil with Cyclosporin A: Preliminary Results on a Surrogate Marker of Drug-Resistant Epilepsy.

1 reference

12 December 2020

Matrix metalloproteinase-9 (MMP-9) in human intractable epilepsy caused by focal cortical dysplasia.

1 reference

12 December 2020

Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

1 reference

12 December 2020

Adjunctive use of verapamil in patients with refractory temporal lobe epilepsy: a pilot study.

1 reference

12 December 2020

Disruption of the blood-brain barrier after generalized tonic-clonic seizures correlates with cerebrospinal fluid MMP-9 levels

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12 December 2020

Challenges in the clinical development of new antiepileptic drugs

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12 December 2020

Pharmacology of cannabinoids in the treatment of epilepsy

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12 December 2020

Epileptiform activity induces vascular remodeling and zonula occludens 1 downregulation in organotypic hippocampal cultures: role of VEGF signaling pathways.

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12 December 2020

Why and how to target angiogenesis in focal epilepsies

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12 December 2020

Brain regional pharmacokinetics of 11C-labeled diphenylhydantoin: positron emission tomography in humans.

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12 December 2020

Magnetic resonance imaging in the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats

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12 December 2020

Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains

1 reference

12 December 2020

Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain

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12 December 2020

P-glycoprotein Expression and Pharmacoresistant Epilepsy: Cause or Consequence?

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12 December 2020

In vivo P-glycoprotein function before and after epilepsy surgery.

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12 December 2020

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy

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12 December 2020

Increased expression of matrix metalloproteinase 9 in cortical lesions from patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.

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12 December 2020

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

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12 December 2020

Drug transport across the blood-brain barrier

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12 December 2020

Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.

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12 December 2020

Redistribution of PDGFRβ cells and NG2DsRed pericytes at the cerebrovasculature after status epilepticus

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12 December 2020

Coexistence of passive and carrier-mediated processes in drug transport

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12 December 2020

TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis

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12 December 2020

A kindling model of pharmacoresistant temporal lobe epilepsy in Sprague-Dawley rats induced by Coriaria lactone and its possible mechanism

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12 December 2020

Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats.

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12 December 2020

Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus

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12 December 2020

Physiopathological mechanisms of post-traumatic epilepsy

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12 December 2020

Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.

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12 December 2020

Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study

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12 December 2020

Measuring Biomarker Progress

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12 December 2020

Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors.

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12 December 2020

The transport of ketone bodies into the brain of the rat (in vivo)

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12 December 2020

Antagonism of peripheral inflammation reduces the severity of status epilepticus.

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12 December 2020

DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity.

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12 December 2020

Development, maintenance and disruption of the blood-brain barrier

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12 December 2020

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

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12 December 2020

Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?

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12 December 2020

10.1208/S12248-017-0096-2

Identifiers

DOI

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Dimensions Publication ID

11 September 2017

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