(Q39340083)

English

Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism

scientific article published on 29 May 2012

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scholarly article

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Europe PubMed Central

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11 September 2017

Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism (English)

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

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Maria Flavia Di Renzo

10

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Maria Flavia Di Renzo

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Europe PubMed Central

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11 September 2017

Chiara Bardella

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Chiara Bardella

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Martina Olivero

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Martina Olivero

2

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Julie Adam

5

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8

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Ian Tomlinson

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11 September 2017

author name string

Annalisa Lorenzato

3

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Europe PubMed Central

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11 September 2017

Massimo Geuna

4

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11 September 2017

Linda O'Flaherty

6

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Europe PubMed Central

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11 September 2017

Pierre Rustin

7

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11 September 2017

Patrick J Pollard

9

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11 September 2017

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publication date

29 May 2012

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11 September 2017

Molecular and Cellular Biology

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11 September 2017

32

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11 September 2017

15

1 reference

Europe PubMed Central

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11 September 2017

3081-3094

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

1 reference

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The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

1 reference

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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

1 reference

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Hypoxia-inducible factors and the response to hypoxic stress

1 reference

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AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF

1 reference

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AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

1 reference

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

1 reference

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Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

1 reference

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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Hypoxia-inducible factors: central regulators of the tumor phenotype

1 reference

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5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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12 December 2020

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Identifiers

10.1128/MCB.06160-11

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

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