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Senescence in Health and Disease.
scientific article published on June 2017
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
review article
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stated in
Europe PubMed Central
title
Senescence in Health and Disease
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author
Shenghui He
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author name string
Norman E Sharpless
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
language of work or name
English
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publication date
1 June 2017
1 reference
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Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
published in
Cell
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Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
volume
169
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
issue
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
page(s)
1000-1011
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
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NKG2D ligands mediate immunosurveillance of senescent cells
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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.
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Cellular senescence in aging and age-related disease: from mechanisms to therapy
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Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.
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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
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17 June 2018
Autologous hematopoietic stem cell transplant induces the molecular aging of T-cells in multiple myeloma
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An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
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Senescence and apoptosis: dueling or complementary cell fates?
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17 June 2018
Inside and out: the activities of senescence in cancer.
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17 June 2018
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17 June 2018
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Geriatric muscle stem cells switch reversible quiescence into senescence.
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p16INK4a reporter mice reveal age-promoting effects of environmental toxicants
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Cell fusion induced by ERVWE1 or measles virus causes cellular senescence
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Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a
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A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage
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17 June 2018
Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations
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17 June 2018
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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17 June 2018
PDGF signalling controls age-dependent proliferation in pancreatic β-cells
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17 June 2018
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
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17 June 2018
Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.
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17 June 2018
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BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation
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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
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17 June 2018
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
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17 June 2018
Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes
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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
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Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.
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Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation
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Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
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17 June 2018
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis
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17 June 2018
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
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17 June 2018
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
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17 June 2018
Growth stimulation leads to cellular senescence when the cell cycle is blocked
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17 June 2018
Chemokine signaling via the CXCR2 receptor reinforces senescence
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17 June 2018
Relationships between stem cell exhaustion, tumour suppression and ageing
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17 June 2018
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
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17 June 2018
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
p16INK4a induces an age-dependent decline in islet regenerative potential
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Ink4a/Arf expression is a biomarker of aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Modulation of mammalian life span by the short isoform of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Principles of tumor suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Phosphorylation of serine 18 regulates distinct p53 functions in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
The serial cultivation of human diploid cell strains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Senescence-like changes induced by expression of p21(waf1/Cip1) in NIH3T3 cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
p53 mutant mice that display early ageing-associated phenotypes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
17 June 2018
mTOR signaling in melanoma: oncogene-induced pseudo-senescence?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Programmed cell senescence during mammalian embryonic development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Cellular senescence in aging primates.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
21 August 2018
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
2 December 2018
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5643029
retrieved
2 December 2018
p16 INK4a can initiate an autonomous senescence program
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28575665
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
DNA damage response and cellular senescence in tissues of aging mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28575665
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28575665
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2017.05.015
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PMC publication ID
5643029
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed publication ID
28575665
1 reference
stated in
Europe PubMed Central
PMC publication ID
5643029
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28575665%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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