(Q39383485)

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FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis.

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25 January 2020

FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis (English)

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25 January 2020

protein ubiquitination

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Antje Willuweit

3

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25 January 2020

author name string

Tomomichi Watanabe

1

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25 January 2020

Yukiko Hikichi

2

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25 January 2020

Yasushi Shintani

4

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25 January 2020

Takashi Horiguchi

5

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25 January 2020

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1 March 2012

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25 January 2020

Journal of Neuroscience

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25 January 2020

32

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25 January 2020

3352-3365

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25 January 2020

10

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25 January 2020

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic Medical Research Award. The ubiquitin system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective ubiquitination of cerebral proteins in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein regulation by monoubiquitin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin enters the new millennium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of intracellular Abeta42 accumulation in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid generation of inducible mouse mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clathrin-independent endocytosis of ubiquitinated cargos

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome dysfunction in aged human alpha-synuclein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation and neuroimaging measures in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polarized endocytosis by Madin-Darby canine kidney cells transfected with functional chicken liver glycoprotein receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin, cellular inclusions and their role in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22399757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5659-11.2012

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22399757%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22399757%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22399757%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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