(Q39436597)

12 September 2017

title

Repression of cancer cell senescence by PKCι. (English)

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12 September 2017

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J A Paget

1

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12 September 2017

I J Restall

2

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12 September 2017

M Daneshmand

3

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12 September 2017

J A Mersereau

4

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12 September 2017

M A Simard

5

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12 September 2017

D A E Parolin

6

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12 September 2017

S J Lavictoire

7

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12 September 2017

M S Amin

8

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12 September 2017

S Islam

9

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12 September 2017

I A J Lorimer

10

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12 September 2017

language of work or name

English

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publication date

28 November 2011

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12 September 2017

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12 September 2017

volume

31

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12 September 2017

issue

31

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12 September 2017

page(s)

3584-3596

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https://scigraph.springernature.com/pub.10.1038/onc.2011.524

12 September 2017

exact match

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cites work

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

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Coordination of glioblastoma cell motility by PKCι

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Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Ciota-mediated attenuation of p38 MAP kinase signaling.

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Regulation of glioblastoma cell invasion by PKC iota and RhoB.

21 January 2018

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A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

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Aurora-A: the maker and breaker of spindle poles

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Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.

21 January 2018

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PTEN level in tumor suppression: how much is too little?

21 January 2018

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

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PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer

21 January 2018

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A DNA damage checkpoint response in telomere-initiated senescence

21 January 2018

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Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

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Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo

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Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

21 January 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

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Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

21 January 2018

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Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

21 January 2018

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Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites.

21 January 2018

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

21 January 2018

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Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation

21 January 2018

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A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

21 January 2018

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

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MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo

21 January 2018

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Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

21 January 2018

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Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

Mutation of the PIK3CA oncogene in human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

Quantitative assessment of markers for cell senescence.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

Targeting retrovirus to cancer cells expressing a mutant EGF receptor by insertion of a single chain antibody variable domain in the envelope glycoprotein receptor binding lobe

21 January 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

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The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

Feedback between p21 and reactive oxygen production is necessary for cell senescence

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

The nuts and bolts of AGC protein kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

Small-molecule inhibitors of PDK1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.524

High frequency of BRAF mutations in nevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancer correlates with the pathologic type of these tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.524

21 January 2018

Identifiers

DOI

10.1038/ONC.2011.524

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12 September 2017

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