(Q39457919)

English

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta

scientific article published on 21 April 2008

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scholarly article

1 reference

Europe PubMed Central

12 September 2017

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta (English)

1 reference

Europe PubMed Central

12 September 2017

Alzheimer's disease

0 references

Hiroshi Ichinose

9

1 reference

Europe PubMed Central

12 September 2017

author name string

Masafumi Shimojo

1

1 reference

Europe PubMed Central

12 September 2017

Naruhiko Sahara

2

1 reference

Europe PubMed Central

12 September 2017

Tatsuya Mizoroki

3

1 reference

Europe PubMed Central

12 September 2017

Satoru Funamoto

4

1 reference

Europe PubMed Central

12 September 2017

Maho Morishima-Kawashima

5

1 reference

Europe PubMed Central

12 September 2017

Takashi Kudo

6

1 reference

Europe PubMed Central

12 September 2017

Masatoshi Takeda

7

1 reference

Europe PubMed Central

12 September 2017

Yasuo Ihara

8

1 reference

Europe PubMed Central

12 September 2017

Akihiko Takashima

10

1 reference

Europe PubMed Central

12 September 2017

language of work or name

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publication date

21 April 2008

1 reference

Europe PubMed Central

12 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

12 September 2017

283

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Europe PubMed Central

12 September 2017

24

1 reference

Europe PubMed Central

12 September 2017

16488-16496

1 reference

Europe PubMed Central

12 September 2017

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Presenilin: running with scissors in the membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Specific Compositions of Amyloid-β Peptides as the Determinant of Toxic β-Aggregation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Abeta40 inhibits amyloid deposition in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

APP processing and synaptic function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801279200

21 January 2018

Identifiers

10.1074/JBC.M801279200

1 reference

Europe PubMed Central

12 September 2017

1 reference

Europe PubMed Central

12 September 2017

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