(Q39505275)

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CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.

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7 February 2020

CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute (English)

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7 February 2020

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7 February 2020

Gabriele Zoppoli

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7 February 2020

Stéphanie Solier

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7 February 2020

William Reinhold

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7 February 2020

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H Liu

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7 February 2020

J W Connelly

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7 February 2020

A Monks

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7 February 2020

R H Shoemaker

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7 February 2020

O D Abaan

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7 February 2020

P S Meltzer

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7 February 2020

J H Doroshow

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7 February 2020

Y Pommier

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7 February 2020

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18 July 2011

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7 February 2020

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7 February 2020

31

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7 February 2020

403-418

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7 February 2020

4

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7 February 2020

https://scigraph.springernature.com/pub.10.1038/onc.2011.283

0 references

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

CHK2 kinase--a busy messenger.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

GammaH2AX and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

ATM activation is accompanied with earlier stages of prostate tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Activated checkpoint kinase 2 provides a survival signal for tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

DNA damage checkpoint kinase Chk2 triggers replicative senescence

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The DNA damage response: ten years after

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Analysis of Food and Drug Administration-approved anticancer agents in the NCI60 panel of human tumor cell lines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Regulation of CHK2 by DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The CHEK2 gene and inherited breast cancer susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

SIFT: Predicting amino acid changes that affect protein function

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

A gene expression database for the molecular pharmacology of cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The NCI60 human tumour cell line anticancer drug screen

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Alternative splicing and mutation status of CHEK2 in stage III breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Chk2 activates E2F-1 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Concomitant inactivation of p53 and Chk2 in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Centrosomal localization of DNA damage checkpoint proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Detection of in vitro kinase generated protein phosphorylation sites using gamma[18O4]-ATP and mass spectrometry

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

21 January 2018

Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

31 March 2020

Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

31 March 2020

Human DNA damage checkpoints and their relevance to soft tissue sarcoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

31 March 2020

Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

31 March 2020

Chk2 molecular interaction map and rationale for Chk2 inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

31 March 2020

Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.283

31 March 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Karyotypic complexity of the NCI-60 drug-screening panel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of checkpoint kinase 2 in breast carcinomas: correlation with key regulators of tumor cell proliferation, angiogenesis, and survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21765476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2011.283

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21765476%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21765476%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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