(Q39527536)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21659333%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1 (English)

1 reference

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3 February 2020

1 reference

1 reference

6

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3 February 2020

author name string

Mónica Sancho

1

1 reference

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3 February 2020

Andrés E Herrera

2

1 reference

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3 February 2020

Anna Gortat

3

1 reference

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3 February 2020

Rodrigo J Carbajo

4

1 reference

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3 February 2020

Antonio Pineda-Lucena

5

1 reference

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3 February 2020

Enrique Pérez-Payá

7

1 reference

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3 February 2020

publication date

9 June 2011

1 reference

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3 February 2020

published in

Human Molecular Genetics

1 reference

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3 February 2020

volume

20

1 reference

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3 February 2020

issue

18

1 reference

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3 February 2020

page(s)

3545-3553

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21659333%20AND%20SRC:MED&resulttype=core&format=json

Inhibition of human caspases by peptide-based and macromolecular inhibitors

3 February 2020

cites work

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Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.

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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

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Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis

21 January 2018

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Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease

21 January 2018

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

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An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

21 January 2018

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Minocycline: A review of its antibacterial and pharmacokinetic properties and therapeutic use

21 January 2018

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Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

21 January 2018

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Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

21 January 2018

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Minocycline and neurodegenerative diseases

21 January 2018

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Tetracyclines: nonantibiotic properties and their clinical implications

21 January 2018

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Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons

21 January 2018

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Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury

21 January 2018

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Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO.

21 January 2018

1 reference

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Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis

21 January 2018

1 reference

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Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria

21 January 2018

1 reference

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Effects of minocycline on Fas-mediated fulminant hepatitis in mice

21 January 2018

1 reference

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Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline

21 January 2018

1 reference

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Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline

21 January 2018

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Huntington's disease: the challenge for cell biologists

21 January 2018

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Huntington's disease: from pathology and genetics to potential therapies

21 January 2018

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

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Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

21 January 2018

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Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

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A unified model for apical caspase activation

21 January 2018

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Oncogene-dependent apoptosis is mediated by caspase-9.

21 January 2018

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Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis

21 January 2018

1 reference

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Cell-free systems to study apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

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Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

21 January 2018

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NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors

21 January 2018

1 reference

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WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

21 January 2018

1 reference

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

21 January 2018

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Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength

21 January 2018

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A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint

21 January 2018

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Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

21 January 2018

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Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin

21 January 2018

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Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

21 January 2018

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Mitochondria, Bcl-2 family proteins and apoptosomes: of worms, flies and men.

21 January 2018

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Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

21 January 2018

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The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.

21 January 2018

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Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat.

21 January 2018

1 reference

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The endoplasmic reticulum and the unfolded protein response

21 January 2018

1 reference

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Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

21 January 2018

1 reference

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Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

21 January 2018

1 reference

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Bcl-xL does not inhibit the function of Apaf-1.

21 January 2018

1 reference

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Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

21 January 2018

1 reference

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Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL.

21 January 2018

1 reference

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Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis

21 January 2018

1 reference

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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

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No death without life: vital functions of apoptotic effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

Structure of the apoptotic protease-activating factor 1 bound to ADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

Caspases: preparation and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR271

21 January 2018

Identifiers

DOI

10.1093/HMG/DDR271

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21659333%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference