(Q39533990)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21623356%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Kinase inhibitors modulate huntingtin cell localization and toxicity (English)

1 reference

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2 February 2020

4

1 reference

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2 February 2020

author name string

Randy Singh Atwal

1

1 reference

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2 February 2020

Carly R Desmond

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21623356%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Nicholas Caron

3

1 reference

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2 February 2020

Jianrun Xia

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21623356%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Simonetta Sipione

6

1 reference

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2 February 2020

Ray Truant

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21623356%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

publication date

29 May 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21623356%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

published in

Nature Chemical Biology

1 reference

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2 February 2020

volume

7

1 reference

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2 February 2020

issue

7

1 reference

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2 February 2020

page(s)

453-460

1 reference

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https://scigraph.springernature.com/pub.10.1038/nchembio.582

2 February 2020

exact match

0 references

cites work

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Secondary Structure of Huntingtin Amino-Terminal Region

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The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

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Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent

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Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

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Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

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SUMO modification of Huntingtin and Huntington's disease pathology

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Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

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Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

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Early or late-stage anti-N-terminal Huntingtin intrabody gene therapy reduces pathological features in B6.HDR6/1 mice

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Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin

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Stochastic kinetics of intracellular huntingtin aggregate formation.

21 January 2018

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Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

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p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease

21 January 2018

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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice

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Using circular dichroism spectra to estimate protein secondary structure

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

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Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts

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BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

21 January 2018

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21 January 2018

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PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains

21 January 2018

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21 January 2018

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The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

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Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production in macrophages: structural requirements of stilbenes for the activity

21 January 2018

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The human IKKbeta subunit kinase domain displays CK2-like phosphorylation specificity.

21 January 2018

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Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation

21 January 2018

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21 January 2018

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Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

21 January 2018

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Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21623356

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21623356

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21623356