(Q39594881)

13 September 2017

title

Phospho-Smad1 modulation by nedd4 E3 ligase in BMP/TGF-β signaling (English)

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13 September 2017

Byung-Gyu Kim

1

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13 September 2017

Ji-Hyun Lee

2

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13 September 2017

Jiro Yasuda

3

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13 September 2017

Hyun-Mo Ryoo

4

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13 September 2017

Je-Yoel Cho

5

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13 September 2017

publication date

1 July 2011

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Journal of Bone and Mineral Research

13 September 2017

published in

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13 September 2017

volume

26

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13 September 2017

issue

7

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13 September 2017

page(s)

1411-1424

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TGFbeta signaling in growth control, cancer, and heritable disorders

13 September 2017

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BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression

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Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

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Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells

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TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

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Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation

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Signal transduction by the TGF-beta superfamily

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Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease

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The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors

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Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.

21 January 2018

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Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

21 January 2018

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Phospho-control of TGF-beta superfamily signaling

21 January 2018

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Regulation of TGF-beta family signaling by E3 ubiquitin ligases

21 January 2018

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Identification of phosphatases for Smad in the BMP/DPP pathway

21 January 2018

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

21 January 2018

1 reference

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

21 January 2018

1 reference

Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways

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Analysis of Nedd4 expression during skeletal development in the mouse limb.

21 January 2018

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The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension

21 January 2018

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Abnormal development of the neuromuscular junction in Nedd4-deficient mice

21 January 2018

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Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

21 January 2018

1 reference

cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene.

21 January 2018

1 reference

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes

21 January 2018

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Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

21 January 2018

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Nedd4 regulates egress of Ebola virus-like particles from host cells

21 January 2018

1 reference

Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process

21 January 2018

1 reference

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

21 January 2018

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Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

21 January 2018

1 reference

The Nedd4-like family of E3 ubiquitin ligases and cancer

21 January 2018

1 reference

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

21 January 2018

1 reference

BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

21 January 2018

1 reference

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

21 January 2018

1 reference

Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

21 January 2018

1 reference

ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes

21 January 2018

1 reference

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JBMR.348

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13 September 2017

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