(Q39720714)

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Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

scientific article published on 31 March 2010

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29 January 2020

Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells (English)

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29 January 2020

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29 January 2020

Peter Barrett-Lee

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29 January 2020

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Peter Barnfather

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29 January 2020

Edd Hayes

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29 January 2020

Pamela Bramble

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29 January 2020

James Christensen

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29 January 2020

Robert I Nicholson

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29 January 2020

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31 March 2010

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29 January 2020

Breast Cancer Research and Treatment

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29 January 2020

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29 January 2020

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29 January 2020

659-669

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29 January 2020

https://scigraph.springernature.com/pub.10.1007/s10549-010-0857-4

0 references

Focal adhesion kinase: a potential target in cancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Mitogenic signaling pathways induced by G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

The urokinase receptor as an entertainer of signal transduction

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Epidermal growth factor stimulates matrix metalloproteinase-9 expression and invasion in human follicular thyroid carcinoma cells through Focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion

1 reference

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21 January 2018

Control of adhesion-dependent cell survival by focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Differential regulation of cell motility and invasion by FAK

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Specific induction of pp125 focal adhesion kinase in human breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

The Biology of Antihormone Failure in Breast Cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Metastatic breast cancer: an updating

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Cellular characterization of a novel focal adhesion kinase inhibitor

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839).

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

alpha- and gamma-Protocadherins negatively regulate PYK2

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Mislocalization of cell-cell adhesion complexes in tamoxifen-resistant breast cancer cells with elevated c-Src tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Focal adhesion kinase: in command and control of cell motility

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Elevated Src kinase activity attenuates Tamoxifen response in vitro and is associated with poor prognosis clinically

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of anti-growth factor therapies to treat or delay endocrine resistance in breast cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-010-0857-4

21 January 2018

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