(Q39762792)

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The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex.

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15 January 2020

The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex (English)

1 reference

Europe PubMed Central

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15 January 2020

Aristotelis Astrinidis

1

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15 January 2020

author name string

Jiyoon Kim

2

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15 January 2020

Crystal M Kelly

3

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15 January 2020

Beatrix A Olofsson

4

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15 January 2020

Behzad Torabi

5

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15 January 2020

Elena M Sorokina

6

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15 January 2020

Jane Azizkhan-Clifford

7

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15 January 2020

publication date

1 March 2010

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15 January 2020

Genes, Chromosomes and Cancer

1 reference

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15 January 2020

49

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15 January 2020

3

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15 January 2020

282-297

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15 January 2020

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

Checking out the centrosome

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

Molecular cloning and analysis of the 5'-flanking region of the rat PP1 alpha gene

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

The BRCA1 E3 ubiquitin ligase controls centrosome dynamics

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

Developmental expression of Sp1 in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

Transcription factor Sp1 expression in gastric cancer and its relationship to long-term prognosis

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

21 January 2018

BRCA1–Sp1 interactions in transcriptional regulation of the IGF‐IR gene

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteomic characterization of the human centrosome by protein correlation profiling

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure and duplication of the centrosome

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Rootletin forms centriole-associated filaments and functions in centrosome cohesion

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Growth/cell cycle regulation of Sp1 phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Fibroblast Growth Factor-2 Represses Platelet-derived Growth Factor Receptor-α (PDGFR-α) Transcription via ERK1/2-dependent Sp1 Phosphorylation and an Atypical cis-Acting Element in the Proximal PDGFR-α Promoter

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage induces Chk1-dependent centrosome amplification.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenic tyrosine kinase of malignant hemopathy targets the centrosome.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Duplicating dangerously: linking centrosome duplication and aneuploidy

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenes and tumour suppressors take on centrosomes

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal centrosome amplification in the absence of p53.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Axin localizes to the centrosome and is involved in microtubule nucleation

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Defining the role of mTOR in cancer

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Predisposition to tetraploidy in pulmonary vascular smooth muscle cells derived from the Eker rats.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of Sp1 activity by a cyclin A/CDK complex

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

PKB/AKT is involved in resumption of meiosis in mouse oocytes

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositide 3-Kinase Binds Constitutively to / -Tubulin and Binds to -Tubulin in Response to Insulin

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp2 localizes to subnuclear foci associated with the nuclear matrix

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Basal transcriptional regulation of human damage-specific DNA-binding protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Survivin modulates microtubule dynamics and nucleation throughout the cell cycle

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of S6K2 as a centrosome-located kinase

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Centrosome splitting in neutrophils: an unusual phenomenon related to cell activation and motility

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppressor p53 represses transcription of RECQ4 helicase

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

From polyploidy to aneuploidy, genome instability and cancer

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of p53 and centrosome hyperamplification.

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Polo-like kinases and Chk2 at the interface of DNA damage checkpoint pathways and mitotic regulation

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

GFP-centrin as a marker for centriole dynamics in living cells

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

TOR signaling in growth and metabolism

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Sp1 and Sp3 regulate basal transcription of the survivin gene

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

Centrosomal localization of DNA damage checkpoint proteins

1 reference

https://api.crossref.org/works/10.1002%2FGCC.20739

7 January 2021

based on heuristic

inferred from DOI database lookup

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