(Q39885234)

15 September 2017

title

Intranasal delivery--modification of drug metabolism and brain disposition (English)

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15 September 2017

Yin Cheong Wong

1

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author name string

Zhong Zuo

series ordinal

2

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15 September 2017

publication date

6 April 2010

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15 September 2017

published in

Pharmaceutical Research

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15 September 2017

volume

27

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15 September 2017

issue

7

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15 September 2017

page(s)

1208-1223

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Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier

15 September 2017

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Development of a human nasal epithelial cell culture model and its suitability for transport and metabolism studies under in vitro conditions

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Nasal administration of opioids for pain management in adults

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Intranasal drug delivery for brain targeting.

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Does Increasing the Lipophilicity of Peptides Enhance Their Nasal Absorption?

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Can nasal drug delivery bypass the blood-brain barrier?: questioning the direct transport theory

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Functional evidence for P-glycoprotein at the nose-brain barrier

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Benzodiazepine concentrations in brain directly reflect receptor occupancy: studies of diazepam, lorazepam, and oxazepam

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Systematic review of factors affecting the ratios of morphine and its major metabolites

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Direct transport of cocaine from the nasal cavity to the brain following intranasal cocaine administration in rats

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Active metabolites of antidepressants: pharmacodynamics and relevant pharmacokinetics

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Preliminary studies of the pharmacokinetics and tolerability of zolmitriptan nasal spray in healthy volunteers

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Nasal mucociliary clearance as a factor in nasal drug delivery

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Effects of intranasal corticosteroids on adrenal, bone, and blood markers of systemic activity in allergic rhinitis

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Pharmacokinetics of ciclesonide and desisobutyryl ciclesonide after administration via aqueous nasal spray or hydrofluoroalkane nasal aerosol compared with orally inhaled ciclesonide: an open-label, single-dose, three-period crossover study in healt

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Intranasal diamorphine as an alternative to intramuscular morphine: pharmacokinetic and pharmacodynamic aspects

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Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites

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12 December 2020

A metabolic explantation for differences between species of the anticonvulsant activity of diazepam

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12 December 2020

Hydrolysis of peptides in the nasal cavity of humans

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12 December 2020

Evaluation of the degradation of desamino1,D-arginine8-vasopressin by nasal mucosa

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12 December 2020

Study of nasal enzyme activity towards insulin. In vitro

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12 December 2020

Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium

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12 December 2020

Bioequivalence and rapid absorption of zolmitriptan nasal spray compared with oral tablets in healthy Japanese subjects

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12 December 2020

Transport of drugs from the nasal cavity to the central nervous system

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Drug metabolism in the nasal cavity: relevance to toxicology

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12 December 2020

Nasal absorption and pharmacokinetic disposition of salmon calcitonin modified with low molecular weight polyethylene glycol

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12 December 2020

Measures for detecting systemic bioactivity with inhaled and intranasal corticosteroids

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12 December 2020

Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats

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12 December 2020

Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam.

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12 December 2020

Comparative localization of carboxylesterase in F344 rat, beagle dog, and human nasal tissue

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12 December 2020

Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature

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12 December 2020

Active metabolites of neuroleptic drugs: possible contribution to therapeutic and toxic effects

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12 December 2020

Enhancement of the systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs

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12 December 2020

Intranasal delivery to the central nervous system: mechanisms and experimental considerations

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12 December 2020

Evaluation of the contribution of the nasal cavity and gastrointestinal tract to drug absorption following nasal application to rats

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12 December 2020

Human nasal mucosal carboxypeptidase: activity, location, and release

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12 December 2020

Morphine-3-glucuronide--a potent antagonist of morphine analgesia

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12 December 2020

Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats

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12 December 2020

Mechanism of nasal absorption of drugs. III: Nasal absorption of leucine enkephalin

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12 December 2020

Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray. A study in healthy volunteers

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12 December 2020

Effects of concentration and volume on nasal bioavailability and biological response to desmopressin

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12 December 2020

Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants

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12 December 2020

Direct nose-to-brain transfer of morphine after nasal administration to rats

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12 December 2020

Direct transport of 2',3'-didehydro-3'-deoxythymidine (D4T) and its ester derivatives to the cerebrospinal fluid via the nasal mucous membrane in rats

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12 December 2020

Nasal epithelial permeation of thymotrinan (TP3) versus thymocartin (TP4): competitive metabolism and self-enhancement

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12 December 2020

Targeted brain delivery of 17 beta-estradiol via nasally administered water soluble prodrugs

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12 December 2020

Accumulation and turnover of metabolites of toluene and xylene in nasal mucosa and olfactory bulb in the mouse

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12 December 2020

Plasma concentrations of heroin and morphine-related metabolites after intranasal and intramuscular administration

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12 December 2020

Role of active metabolites in the use of opioids

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12 December 2020

Pharmacokinetics of substrate uptake and distribution in murine brain after nasal instillation

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Xenobiotic-metabolizing enzymes in human respiratory nasal mucosa

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12 December 2020

Nasal drug delivery--possibilities, problems and solutions

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12 December 2020

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12 December 2020

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12 December 2020

Intranasal administration of peptides: nasal deposition, biological response, and absorption of desmopressin

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12 December 2020

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12 December 2020

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12 December 2020

Characterization of human nasal primary culture systems to investigate peptide metabolism

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12 December 2020

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12 December 2020

Active drug metabolites in drug development

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12 December 2020

Aminopeptidase activity in human nasal mucosa

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12 December 2020

Mechanistic appraisal of the effects of some protease inhibitors on ciliary beat frequency in a sequential cell culture system of human nasal epithelium

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12 December 2020

Metabolism of diethylnitrosamine by microsomes of human respiratory nasal mucosa and liver

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12 December 2020

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12 December 2020

Nasal mucosal metabolism and absorption of pentapeptide enkephalin analogs having varying N-terminal amino acids

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12 December 2020

Nasal absorption enhancement strategies for therapeutic peptides: an in vitro study using cultured human nasal epithelium

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12 December 2020

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery

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12 December 2020

Morphine-6-glucuronide: actions and mechanisms

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12 December 2020

Disposition of parenteral butorphanol in man

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12 December 2020

A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis

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12 December 2020

Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.

1 reference

12 December 2020

Nasal delivery of peptides: an in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium

1 reference

12 December 2020

Hydrolysis of leucine enkephalin in the nasal cavity of the rat--a possible factor in the low bioavailability of nasally administered peptides

1 reference

12 December 2020

Mechanism of nasal absorption of drugs. II: Absorption of L-tyrosine and the effect of structural modification on its absorption

1 reference

12 December 2020

In vitro metabolism of ciclesonide in human nasal epithelial cells

1 reference

12 December 2020

Pharmacokinetic evaluation and modeling of formulated levodopa intranasal delivery systems

1 reference

12 December 2020

Formed and preformed metabolites: facts and comparisons.

1 reference

12 December 2020

High-affinity nasal extraction of vinyl acetate vapor is carboxylesterase dependent.

1 reference

12 December 2020

Degradation of [mercaptopropionic acid1, D-arginine8]-vasopressin (dDAVP) in pancreatic juice and intestinal mucosa homogenate

1 reference

12 December 2020

Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam.

1 reference

12 December 2020

Pharmacokinetics and brain uptake of diazepam after intravenous and intranasal administration in rats and rabbits

1 reference

12 December 2020

Metabolites and safety: What are the concerns, and how should we address them?

1 reference

12 December 2020

Disposition of nasal, intravenous, and oral methadone in healthy volunteers

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12 December 2020

Direct nose-brain transport of benzoylecgonine following intranasal administration in rats

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12 December 2020

Recovery of rat nasal mucosa from the effects of aminopeptidase inhibitors

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12 December 2020

10.1007/S11095-010-0127-5

Identifiers

DOI

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15 September 2017

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