(Q39946663)

English

The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats

scientific article

The Novel Cholinesterase–Monoamine Oxidase Inhibitor and Antioxidant, Ladostigil, Confers Neuroprotection in Neuroblastoma Cells and Aged Rats

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

1 reference

based on heuristic

inferred from title

Moussa B. H. Youdim

4

object named as

Moussa B H Youdim

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

2

object named as

Orly Weinreb

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

author name string

Orit Bar-Am

1

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

Tamar Amit

3

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

publication date

27 August 2008

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

Journal of Molecular Neuroscience

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

37

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

135-145

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9139-6

21 January 2018

Redox signaling: hydrogen peroxide as intracellular messenger

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9139-6

21 January 2018

Oxidative stress in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12031-008-9139-6

21 January 2018

Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide regulates the cholinergic signal in a concentration dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of selegiline on antioxidant systems in the nigrostriatum in rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The establishment of a reliable cytotoxic system with SK-N-SH neuroblastoma cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide: a signaling messenger

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and aberrant signaling in aging and cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: prevention by ladostigil

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalase in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in glutathione and glutathione-related enzymes in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metal and inflammatory targets for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoamine oxidase expression during development and aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-associated decline in gamma-glutamylcysteine synthetase gene expression in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide radical and superoxide dismutases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinergic hypothesis of Alzheimer's disease: a review of progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of superoxide dismutase and catalase in rat brain as a function of age.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of gamma-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase inhibitors: novel activities of old molecules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to H(2)O(2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline: an anti-Parkinson drug with neuroprotective activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recovery of lens optics and epithelial enzymes after ultraviolet A radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer' s disease, oxidative stress and gammahydroxybutyrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals, metals and antioxidants in oxidative stress-induced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and inflammation in brain aging: nutritional considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetrahydroaminoacridine selectively attenuates NMDA receptor-mediated neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of inhibition of glutathione reductase on the detoxification of H2O2 by rabbit lens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer' disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant properties of propargylamine derivatives: assessment of their ability to scavenge peroxynitrite

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress: free radical production in neural degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial DNA mutations, oxidative stress, and aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of NAD(P)H:quinone oxidoreductase 1 in HeLa cells: role of hydrogen peroxide and growth phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The water extract of Omija protects H9c2 cardiomyoblast cells from hydrogen peroxide through prevention of mitochondrial dysfunction and activation of caspases pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence for antioxidant effect of Bcl-2 in PC12 rat pheochromocytoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species and Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals and antioxidants in normal physiological functions and human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rivastigmine. A pharmacoeconomic review of its use in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12031-008-9139-6

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

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