(Q39982958)

16 September 2017

title

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design (English)

1 reference

16 September 2017

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Almer M van der Sloot

2

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16 September 2017

Eva Szegezdi

4

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Robbert H Cool

object named as

Robbert H Cool

5

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Afshin Samali

object named as

Afshin Samali

6

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author name string

Vicente Tur

1

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16 September 2017

Carlos R Reis

3

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16 September 2017

Luis Serrano

7

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16 September 2017

Wim J Quax

8

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16 September 2017

language of work or name

English

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publication date

12 May 2008

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Journal of Biological Chemistry

16 September 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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16 September 2017

volume

283

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16 September 2017

issue

29

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16 September 2017

page(s)

20560-20568

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Modulating calmodulin binding specificity through computational protein design

16 September 2017

cites work

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Computational redesign of protein-protein interaction specificity

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Safety and antitumor activity of recombinant soluble Apo2 ligand

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Apo2L/TRAIL and its death and decoy receptors

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Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

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TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

21 January 2018

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FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

21 January 2018

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

21 January 2018

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TRAIL receptor-2 signals apoptosis through FADD and caspase-8

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Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

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Following a TRAIL: update on a ligand and its five receptors

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Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

21 January 2018

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Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding

21 January 2018

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Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

21 January 2018

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Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1.

21 January 2018

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TRAIL and its receptors as targets for cancer therapy

21 January 2018

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Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor

21 January 2018

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Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

21 January 2018

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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

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21 January 2018

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Stabilization of TRAIL, an all-beta-sheet multimeric protein, using computational redesign.

21 January 2018

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A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

21 January 2018

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Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling

21 January 2018

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Identification and characterization of a new member of the TNF family that induces apoptosis

21 January 2018

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Inactivation of TNF signaling by rationally designed dominant-negative TNF variants

21 January 2018

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Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6.

21 January 2018

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Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

21 January 2018

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Recognizing and Defining True Ras Binding Domains II: In Silico Prediction Based on Homology Modelling and Energy Calculations

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M800457200

1 reference

16 September 2017

1 reference