(Q40003995)

English

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells

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Europe PubMed Central

PubMed publication ID

16 September 2017

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells (English)

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Europe PubMed Central

PubMed publication ID

16 September 2017

apoptotic process

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1 reference

based on heuristic

inferred from title

5

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

object named as

Elisenda Sanz

1

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Albert Quintana

object named as

Albert Quintana

2

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Mercedes Unzeta

object named as

Mercedes Unzeta

10

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author name string

Valentina Battaglia

3

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Antonio Toninello

4

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Europe PubMed Central

PubMed publication ID

16 September 2017

Santiago Ambrosio

6

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Massimo Valoti

7

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Jose Luis Marco

8

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Keith F Tipton

9

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Europe PubMed Central

PubMed publication ID

16 September 2017

language of work or name

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publication date

1 June 2008

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Europe PubMed Central

PubMed publication ID

16 September 2017

Journal of Neurochemistry

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Europe PubMed Central

PubMed publication ID

16 September 2017

105

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Europe PubMed Central

PubMed publication ID

16 September 2017

6

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Europe PubMed Central

PubMed publication ID

16 September 2017

2404-2417

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Europe PubMed Central

PubMed publication ID

16 September 2017

Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Monoamine oxidase inhibitory potencies and selectivities of 2-[N-(2-propynyl)-aminomethyl]-1-methyl indole derivatives

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Aliphatic propargylamines as symptomatic and neuroprotective treatments for neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Post-translational modification of p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Dissecting p53-dependent apoptosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

The kinetics of monoamine oxidase inhibition by three 2-indolylmethylamine derivatives

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

p53 in neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Neuroprotective effect of the monoamine oxidase inhibitor PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] on rat nigral neurons after 6-hydroxydopamine-striatal lesion

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

MPP+ induced SH-SY5Y apoptosis is potentiated by cyclosporin A and inhibited by aristolochic acid

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Characterization and time course of MPP+ -induced apoptosis in human SH-SY5Y neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine], a new MAO-B inhibitor, attenuates MPTP-induced depletion of striatal dopamine levels in C57/BL6 mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned rats.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

AlphaII-spectrin is an in vitro target for caspase-2, and its cleavage is regulated by calmodulin binding.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

The therapeutic potential of monoamine oxidase inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

No PUMA, no death: implications for p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05326.X

21 January 2018

Identifiers

10.1111/J.1471-4159.2008.05326.X

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

ResearchGate publication ID

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