(Q40254769)

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Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival.

scientific article published on 17 July 2006

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scholarly article

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Europe PubMed Central

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27 December 2019

Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival (English)

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27 December 2019

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27 December 2019

Rizaldy P Scott

2

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27 December 2019

Matthew J. Smith

3

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27 December 2019

5

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27 December 2019

author name string

Tony Pawson

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27 December 2019

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17 July 2006

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27 December 2019

Journal of Biological Chemistry

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27 December 2019

281

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27 December 2019

40

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27 December 2019

29886-29896

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27 December 2019

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Affinity, specificity, and kinetics of the interaction of the SHC phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

GDNF is a chemoattractant for enteric neural cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

The RET proto-oncogene in human cancers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

The GDNF/RET signaling pathway and human diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

RET proto-oncogene in the development of human cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Role of Dok1 in cell signaling mediated by RET tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Memo mediates ErbB2-driven cell motility.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

The activation of Akt/PKB signaling pathway and cell survival.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Critical and distinct roles for key RET tyrosine docking sites in renal development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600473200

21 January 2018

Identifiers

10.1074/JBC.M600473200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847065%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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24 November 2022

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Europe PubMed Central

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27 December 2019

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