(Q40311468)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

GC-selective DNA-binding antibiotic, mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

3

1 reference

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17 January 2020

author name string

A Phillips

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

M Darley

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

27 February 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

4183-4193

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209451

17 January 2020

exact match

0 references

cites work

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Phosphorylation of HDM2 by Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Role of two upstream open reading frames in the translational control of oncogene mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

PTEN regulates Mdm2 expression through the P1 promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Mapping of the p53 and mdm-2 interaction domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Nuclear export of mRNA: from the site of transcription to the cytoplasm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Detection of functional single-nucleotide polymorphisms that affect apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

DNA-damaging aryl hydrocarbons induce Mdm2 expression via p53-independent post-transcriptional mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Identification of p53 regulators by genome-wide functional analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

The two upstream open reading frames of oncogene mdm2 have different translational regulatory properties

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Organizing mRNA export

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Inhibition of p53-mediated transcriptional responses by mithramycin A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

A plausible model for the digital response of p53 to DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

The p53-Mdm2 module and the ubiquitin system.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Mithramycin selectively inhibits transcription of G-C containing DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

The MDM2 gene amplification database

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

The mechanisms of regulation of Hdm2 protein level by serum growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Regulation of the mdm2 oncogene by thyroid hormone receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Induction of Mdm2 and enhancement of cell survival by bFGF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

1 reference

7 January 2021

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

BCR/ABL activates mdm2 mRNA translation via the La antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

The influence of cell context on the selection pressure for p53 mutation in human cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Cyclin a-CDK phosphorylation regulates MDM2 protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209451

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209451

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16501602%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 January 2020

1024843924

0 references

1 reference