(Q40455851)

20 September 2017

title

MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm. (English)

1 reference

20 September 2017

Monika Phelps

1

1 reference

20 September 2017

Anna Phillips

series ordinal

2

1 reference

20 September 2017

Matthew Darley

series ordinal

3

1 reference

20 September 2017

Jeremy P Blaydes

series ordinal

4

1 reference

20 September 2017

language of work or name

English

0 references

publication date

21 February 2005

1 reference

Journal of Biological Chemistry

20 September 2017

published in

1 reference

20 September 2017

volume

280

1 reference

20 September 2017

issue

17

1 reference

20 September 2017

page(s)

16651-16658

1 reference

20 September 2017

cites work

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Phosphorylation of HDM2 by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The dark side of Ras: regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The INK4A/ARF locus and its two gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Induction of Mdm2 and enhancement of cell survival by bFGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Role of two upstream open reading frames in the translational control of oncogene mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

BCR/ABL activates mdm2 mRNA translation via the La antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Messenger RNA turnover in cell-free extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The human Y4 small cytoplasmic RNA gene is controlled by upstream elements and resides on chromosome 7 with all other hY scRNA genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Nuclear export of mRNA: from the site of transcription to the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

RNA metabolism in nuclei: adenovirus and heat shock alter intranuclear RNA compartmentalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Delineation of mRNA export pathways by the use of cell-permeable peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Regulation of p53 expression by the RAS-MAP kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The role of MAPK pathways in the action of chemotherapeutic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The blood-brain barrier and cerebral angiogenesis: lessons from the cold-injury model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412334200

21 January 2018

Identifiers

DOI

10.1074/JBC.M412334200

1 reference

20 September 2017

1 reference