(Q40391790)

English

E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short).

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short) (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

apoptotic process

0 references

1 reference

based on heuristic

inferred from title

Olivier Micheau

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Laurence Chaperot

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

author name string

Salon C

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Eymin B

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Plumas J

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Brambilla C

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Brambilla E

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Gazzeri S

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

publication date

1 February 2006

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Cell Death & Differentiation

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

260-272

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401739

0 references

E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

21 January 2018

The E2F-1 transcription factor promotes caspase-8 and bid expression, and enhances Fas signaling in T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

21 January 2018

Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

21 January 2018

The regulation of E2F by pRB-family proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

The Rb/E2F pathway: expanding roles and emerging paradigms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct roles for E2F proteins in cell growth control and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

E2F-1 functions in mice to promote apoptosis and suppress proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

E2F1 pathways to apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

CASH, a novel caspase homologue with death effector domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of death receptor signals by cellular FLIP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Casper is a FADD- and caspase-related inducer of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of caspases-8 and -10 by FLIP(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct coupling of the cell cycle and cell death machinery by E2F.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

The anti-cancer drug etoposide can induce caspase-8 processing and apoptosis in the absence of CD95 receptor-ligand interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular ordering of the initial signaling events of CD95.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Antitumor cytotoxic T-lymphocyte response in human lung carcinoma: identification of a tumor-associated antigen.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Role for the p53 homologue p73 in E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the p53-homologue p73 in E2F1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Apaf-1 is a mediator of E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Cleavage of E2F-1-regulating proteins and activation of E2F-1 during CD95-induced death of thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of fas death signals by FLIPs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene expression changes in response to E2F1 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective death receptor signaling as a cause of tumor immune escape

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Frequent loss of Fas expression and function in human lung tumours with overexpression of FasL in small cell lung carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401739

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.CDD.4401739

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16052233%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q40391790&oldid=1507492619"