(Q40406480)

English

Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration

scientific article published on January 2004

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration (English)

1 reference

Europe PubMed Central

20 September 2017

vitamin deficiency

0 references

neurodegeneration

1 reference

based on heuristic

inferred from title

2

object named as

Michael Graves

1 reference

Europe PubMed Central

20 September 2017

author name string

Flaubert Tchantchou

1

1 reference

Europe PubMed Central

20 September 2017

Daniela Ortiz

3

1 reference

Europe PubMed Central

20 September 2017

Eugene Rogers

4

1 reference

Europe PubMed Central

20 September 2017

Thomas B Shea

5

1 reference

Europe PubMed Central

20 September 2017

publication date

1 January 2004

1 reference

Europe PubMed Central

20 September 2017

NeuroMolecular Medicine

1 reference

Europe PubMed Central

20 September 2017

6

1 reference

Europe PubMed Central

20 September 2017

2-3

1 reference

Europe PubMed Central

20 September 2017

93-103

1 reference

Europe PubMed Central

20 September 2017

https://scigraph.springernature.com/pub.10.1385/nmm:6:2-3:093

0 references

Cobalamin-dependent methionine synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin E deficiency does not induce compensatory antioxidant increases in central nervous system tissue of apolipoprotein E-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurobiological basis of spontaneous alternation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary factors and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 gene silencing by S‐adenosylmethionine: a treatment for Alzheimer disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine and dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic profiles and functional genomics in Alzheimer's disease and in dementia with a vascular component

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain ATP:L-methionine S-adenosyltransferase (MAT), S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH): regional distribution and age-related changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma folate, vitamin B(12), and total homocysteine and homozygosity for the C677T mutation of the 5,10-methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia. A case-control study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of cell death in Alzheimer's disease: role of presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CSF-folate levels are decreased in late-onset AD patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demyelination and decreased S-adenosylmethionine in 5,10-methylenetetrahydrofolate reductase deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione metabolism during aging and in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Cerebral vascular complication of hyperhomocysteinemia. Controlling thromboembolic complications with folates]

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine, folate deprivation and Alzheimer neuropathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 4,752 C/T polymorphism in the presenilin 1 gene increases the risk of Alzheimer's disease in apolipoprotein E4 carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications on human fertility of the 677C-->T and 1298A-->C polymorphisms of the MTHFR gene: consequences of a possible genetic selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione, oxidative stress and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology of folate and vitamin B12 in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Japanese family with familial Alzheimer's disease associated with presenilin 1 mutation: relationship between younger age of onset and ApoE gene polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects on growth, homocysteine, and related compounds of two inhibitors of S-adenosylhomocysteine catabolism, 3-deazaadenosine, and 3-deazaaristeromycin, in C3H/10T1/2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15970627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/NMM:6:2-3:093

1 reference

Europe PubMed Central

20 September 2017

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0 references

1 reference

Europe PubMed Central

20 September 2017

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