(Q40481710)

English

Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. (English)

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Europe PubMed Central

PubMed publication ID

20 September 2017

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5-fluorocytosine

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author name string

Ute Fischer

1

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Europe PubMed Central

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20 September 2017

Sabine Steffens

2

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Europe PubMed Central

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20 September 2017

Susanne Frank

3

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Europe PubMed Central

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20 September 2017

Nikolai G Rainov

4

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20 September 2017

Klaus Schulze-Osthoff

5

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20 September 2017

Christof M Kramm

6

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20 September 2017

language of work or name

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1 February 2005

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20 September 2017

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20 September 2017

24

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20 September 2017

7

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20 September 2017

1231-1243

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Europe PubMed Central

PubMed publication ID

20 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208290

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Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies

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21 January 2018

Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy

1 reference

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21 January 2018

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

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21 January 2018

Proteolytic cleavage of the mdm2 oncoprotein during apoptosis

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21 January 2018

Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

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21 January 2018

Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis

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21 January 2018

Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy.

1 reference

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21 January 2018

Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation

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21 January 2018

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

1 reference

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21 January 2018

Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir

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21 January 2018

Live or let die: the cell's response to p53

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21 January 2018

S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase.

1 reference

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21 January 2018

The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells.

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7 January 2021

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Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

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Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

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Control of apoptosis by p53.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

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Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

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Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

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Regulation of p53 stability by Mdm2

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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Twenty years of p53 research: structural and functional aspects of the p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

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The DNA damage-induced decrease of Bcl-2 is secondary to the activation of apoptotic effector caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

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Room for expansion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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The 9L rat brain tumor: Description and application of an animal model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208290

7 January 2021

based on heuristic

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Identifiers

10.1038/SJ.ONC.1208290

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

ResearchGate publication ID

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