(Q40573510)

English

Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia

scientific article published on 25 March 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Michael P. Lisanti

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object named as

Michael P Lisanti

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Europe PubMed Central

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21 September 2017

Richard Pestell

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object named as

Richard G Pestell

1 reference

Europe PubMed Central

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21 September 2017

Philipp E. Scherer

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object named as

Philipp E Scherer

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Europe PubMed Central

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21 September 2017

5

object named as

Babak Razani

1 reference

Europe PubMed Central

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21 September 2017

Terence M Williams

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object named as

Terence M Williams

1 reference

Europe PubMed Central

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21 September 2017

2

object named as

Hyangkyu Lee

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Puneeth Iyengar

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object named as

Puneeth Iyengar

1 reference

Europe PubMed Central

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21 September 2017

Michelle Cheung

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object named as

Michelle W-C Cheung

1 reference

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21 September 2017

author name string

Alex W Cohen

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21 September 2017

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publication date

25 March 2004

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Europe PubMed Central

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21 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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21 September 2017

279

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Europe PubMed Central

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21 September 2017

23

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Europe PubMed Central

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21 September 2017

24745-24756

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Caveolin, a protein component of caveolae membrane coats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Emerging themes in lipid rafts and caveolae.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolin-deficient mice: insights into caveolar function human disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Reduction of caveolin and caveolae in oncogenically transformed cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Germline p16 mutations in familial melanoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Modelling the molecular circuitry of cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Baculovirus-based expression of mammalian caveolin in Sf21 insect cells. A model system for the biochemical and morphological study of caveolae biogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402064200

21 January 2018

Identifiers

10.1074/JBC.M402064200

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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