(Q40754542)

23 September 2017

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction (English)

1 reference

23 September 2017

A Y Robin

1

1 reference

23 September 2017

K Krishna Kumar

2

1 reference

23 September 2017

D Westphal

3

1 reference

23 September 2017

A Z Wardak

4

1 reference

23 September 2017

G V Thompson

5

1 reference

23 September 2017

G Dewson

6

1 reference

23 September 2017

P M Colman

7

1 reference

23 September 2017

P E Czabotar

8

1 reference

23 September 2017

9 July 2015

1 reference

23 September 2017

Cell Death and Disease

1 reference

23 September 2017

6

1 reference

23 September 2017

e1809

1 reference

Creative Commons Attribution 4.0 International

23 September 2017

start time

1 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

BID-induced structural changes in BAK promote apoptosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Unusual arginine formations in protein function and assembly: rings, strings, and stacks

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Still embedded together binding to membranes regulates Bcl-2 protein interactions.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Features and development of Coot

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

PHENIX: a comprehensive Python-based system for macromolecular structure solution

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Lessons from the lysozyme of phage T4

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

BAX activation is initiated at a novel interaction site

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Bcl-XL inhibits membrane permeabilization by competing with Bax.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Structural insights into the degradation of Mcl-1 induced by BH3 domains

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Electrostatics of nanosystems: application to microtubules and the ribosome

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Structure of Bax: coregulation of dimer formation and intracellular localization

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Movement of Bax from the cytosol to mitochondria during apoptosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Structural model of active Bax at the membrane.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Molecular details of Bax activation, oligomerization, and membrane insertion.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4650713

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26158515

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2015.141

1 reference

release_vcsh2sbowrfltaywkule53oamm

23 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vcsh2sbowrfltaywkule53oamm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

23 September 2017

PubMed publication ID

26158515

1 reference