(Q41056037)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

title

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Hardik Shah

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

John D. Chodera

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

11

Craig B Thompson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

10

Justin R Cross

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

author name string

Bo Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Hui Liu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Carlos Carmona-Fontaine

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Ariën S Rustenburg

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Salah Salah

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

M R Gunner

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

publication date

6 March 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

page(s)

494-500

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nchembio.2307

4 April 2020

exact match

0 references

cites work

The Emerging Hallmarks of Cancer Metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Hypoxia Induces Production of L-2-Hydroxyglutarate.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Metabolite damage and its repair or pre-emption

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

IDH mutation impairs histone demethylation and results in a block to cell differentiation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

A sensitive fluorimetric assay for pyruvate

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

The role of oxygen availability in embryonic development and stem cell function

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

L-2-hydroxyglutaric aciduria, a defect of metabolite repair

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Oxygen sensing by HIF hydroxylases

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Lactic dehydrogenase. V. Inhibition by oxamate and by oxalate

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

MCCE2: improving protein pKa calculations with extensive side chain rotamer sampling

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Brain levels of NADH and NAD+ under hypoxic and hypoglycaemic conditions in vitro.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Changes in extracellular and intracellular pH in ischemic rabbit papillary muscle

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

L-2-hydroxyglutaric aciduria and brain tumors in children with mutations in the L2HGDH gene: neuroimaging findings

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Reduction of alpha gamma-diketo and alpha-keto acids catalyzed by muscle preparations and by crystalline lactic dehydrogenase.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

HIF activation by pH-dependent nucleolar sequestration of VHL.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5516644

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

19 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

pH Dependence of Lactate Dehydrogenase Isozyme Inhibition by Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

Intracellular pH changes induced by hypoxia and anoxia in isolated sheep heart Purkinje fibres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

7 January 2021

A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of αHG

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

7 January 2021

A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

7 January 2021

Design and synthesis of new enzymes based on the lactate dehydrogenase framework

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

7 January 2021

Epik: a software program for pK( a ) prediction and protonation state generation for drug-like molecules

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

7 January 2021

On the calculation of pKas in proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

7 January 2021

Refinement of protein conformations using a macromolecular energy minimization procedure

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2307

7 January 2021

Reduction of alpha-ketoglutarate by homogeneous lactic dehydrogenase X of testicular tissue

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28263965

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NCHEMBIO.2307

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

release_se2hnt3pnbh67gwyjjcz7c2v7i

4 April 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/se2hnt3pnbh67gwyjjcz7c2v7i

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28263965%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

28263965

1 reference