(Q41119883)

27 September 2017

Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs (English)

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27 September 2017

Plasmodium falciparum

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4

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27 September 2017

Hwa H Chua

2

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Brunda Nijagal

object named as

Brunda Nijagal

3

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Stuart A Ralph

object named as

Stuart A Ralph

5

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author name string

Simon A Cobbold

1

1 reference

PubMed ID

26150544

27 September 2017

Malcolm J McConville

6

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PubMed ID

26150544

27 September 2017

language of work or name

English

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publication date

6 July 2015

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Journal of Infectious Diseases

27 September 2017

11

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based on heuristic

inferred from page(s)

published in

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27 September 2017

213

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27 September 2017

2

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27 September 2017

276-286

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Thousands of chemical starting points for antimalarial lead identification

27 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Chemical genetics of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

The open access malaria box: a drug discovery catalyst for neglected diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Targeting Plasmodium PI(4)K to eliminate malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Chemical signatures and new drug targets for gametocytocidal drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

A domino effect in antifolate drug action in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Current status and progresses made in malaria chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Insights into the role of heme in the mechanism of action of antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Artemisinin: mechanisms of action, resistance and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Methylene blue as an antimalarial agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Oxidative Phosphorylation and Rotenone-insensitive Malate- and NADH-Quinone Oxidoreductases in Plasmodium yoelii yoelii Mitochondria in Situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

The mosquito transmission of malaria: the effects of atovaquone-proguanil (Malarone) and chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Host-parasite interactions revealed by Plasmodium falciparum metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Artemisinins target the SERCA of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV372

21 January 2018

Identifiers

DOI

10.1093/INFDIS/JIV372

1 reference

27 September 2017

1 reference

PubMed ID

26150544