(Q41695461)

7 October 2017

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title

Apoptosis: a new pharmacodynamic endpoint (English)

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7 October 2017

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Au JL

1

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7 October 2017

Panchal N

series ordinal

2

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7 October 2017

Li D

series ordinal

3

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7 October 2017

Gan Y

series ordinal

4

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7 October 2017

publication date

1 December 1997

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7 October 2017

published in

Pharmaceutical Research

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7 October 2017

volume

14

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7 October 2017

issue

12

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7 October 2017

page(s)

1659-1671

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

7 October 2017

cites work

1 reference

12 December 2020

The biochemistry of programmed cell death

1 reference

12 December 2020

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

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12 December 2020

Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness

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12 December 2020

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

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12 December 2020

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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12 December 2020

Cytotoxic T cells overcome BCR-ABL-mediated resistance to apoptosis.

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12 December 2020

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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12 December 2020

Effect of bcl-2 on Fas antigen-mediated cell death

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12 December 2020

Identification of a p53-dependent negative response element in the bcl-2 gene

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12 December 2020

Pharmacodynamics of taxol in human head and neck tumors

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12 December 2020

Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators

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12 December 2020

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

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12 December 2020

Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis

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12 December 2020

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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12 December 2020

Regulation of the Fas apoptotic cell death pathway by Abl.

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12 December 2020

Ultrastructural localization of bcl-2 protein

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12 December 2020

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

1 reference

12 December 2020

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

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12 December 2020

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

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12 December 2020

Cycloheximide inhibits the cytotoxicity of paclitaxel (Taxol)

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12 December 2020

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

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12 December 2020

Activation of p34cdc2 coincident with taxol-induced apoptosis.

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12 December 2020

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

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12 December 2020

18q21 rearrangement in diffuse large cell lymphoma: incidence and clinical significance

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12 December 2020

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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12 December 2020

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice

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12 December 2020

Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA.

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12 December 2020

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

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12 December 2020

Apoptosis. Its significance in cancer and cancer therapy

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12 December 2020

Prevention of vertebrate neuronal death by the crmA gene

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

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12 December 2020

Essential role for p53-mediated transcription in E1A-induced apoptosis

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12 December 2020

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

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12 December 2020

p53 mutations increase resistance to ionizing radiation

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12 December 2020

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

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12 December 2020

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

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12 December 2020

Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.

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12 December 2020

Glucocorticoid-induced apoptosis of lymphoid cells.

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12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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12 December 2020

Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation

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12 December 2020

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells

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12 December 2020

Constitutive expression of the c-H-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line

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12 December 2020

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

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12 December 2020

Bcl-2 expression prevents activation of the ICE protease cascade

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12 December 2020

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

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12 December 2020

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

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12 December 2020

ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis

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12 December 2020

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

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12 December 2020

Induction of apoptosis in fibroblasts by c-myc protein

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12 December 2020

Chapter 3 Assays for DNA Fragmentation, Endonucleases, and Intracellular pH and Ca2+ Associated with Apoptosis

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12 December 2020

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production

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12 December 2020

The comet assay: a comprehensive review

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12 December 2020

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA

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12 December 2020

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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12 December 2020

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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12 December 2020

Protein kinases and cell cycle control

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12 December 2020

Transfection with a bcl-2 expression vector protects transplanted bone marrow from chemotherapy-induced myelosuppression

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12 December 2020

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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12 December 2020

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

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12 December 2020

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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12 December 2020

Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

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12 December 2020

Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

Apoptosis and chemotherapy resistance

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12 December 2020

WAF1, a potential mediator of p53 tumor suppression

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12 December 2020

Role of multiple cellular proteases in the execution of programmed cell death.

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12 December 2020

Apoptosis and the cell cycle.

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12 December 2020

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair

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12 December 2020

Mechanisms of apoptotic cell death

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12 December 2020

Apoptosis by death factor

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12 December 2020

Anatomical methods in cell death

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12 December 2020

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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12 December 2020

Detection of 5-bromo-2-deoxyuridine (BrdUrd) incorporation with monoclonal anti-BrdUrd antibody after deoxyribonuclease treatment

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12 December 2020

p53, the cellular gatekeeper for growth and division

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12 December 2020

A novel domain within the 55 kd TNF receptor signals cell death

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12 December 2020

Methods for the detection of apoptosis

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12 December 2020

ADP-ribosylation of proteins. Enzymology and biological significance.

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12 December 2020

Cells en route to apoptosis are characterized by the upregulation of c‐fos, c‐myc, c‐jun, cdc2, and RB phosphorylation, resembling events of early cell‐cycle traverse

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12 December 2020

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection

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12 December 2020

Apoptosis and therapy of malignant diseases of the hematopoietic system

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12 December 2020

Controlling cell death

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12 December 2020

bcl-2 protein in non-small-cell lung carcinoma

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

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12 December 2020

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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12 December 2020

p53 mutations in human cancers

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12 December 2020

Induction of the growth inhibitor IGF-binding protein 3 by p53

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12 December 2020

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

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12 December 2020

Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.

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12 December 2020

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

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12 December 2020

Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

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12 December 2020

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

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12 December 2020

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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12 December 2020

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme

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12 December 2020

Genomic instability and the role of p53 mutations in cancer cells

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12 December 2020

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

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12 December 2020

Mediation of c-Myc-induced apoptosis by p53.

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12 December 2020

Bcl-2 and the regulation of programmed cell death

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12 December 2020

Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis

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12 December 2020

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B

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12 December 2020

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

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12 December 2020

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

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12 December 2020

Regulation of apoptosis in the immune system

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12 December 2020

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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12 December 2020

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

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12 December 2020

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

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12 December 2020

Mechanisms of Bcl-2 family protein function and dysfunction in health and disease

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12 December 2020

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

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12 December 2020

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

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12 December 2020

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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12 December 2020

Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.

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12 December 2020

Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis).

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12 December 2020

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis

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12 December 2020

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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12 December 2020

RAIDD is a new 'death' adaptor molecule

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12 December 2020

p21 is a universal inhibitor of cyclin kinases

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12 December 2020

Cell death in health and disease: the biology and regulation of apoptosis

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12 December 2020

Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation

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12 December 2020

Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression

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12 December 2020

Molecular cloning of the interleukin-1 beta converting enzyme

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12 December 2020

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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12 December 2020

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12 December 2020

The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model

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12 December 2020

Combinatorial interaction of human bcl-2 related proteins: mapping of regions important for bcl-2/bcl-x-s interaction.

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12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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12 December 2020

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

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12 December 2020

Features of apoptotic cells measured by flow cytometry

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12 December 2020

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer

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12 December 2020

Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32

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12 December 2020

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells

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12 December 2020

Life, death, and the pursuit of apoptosis.

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12 December 2020

Apoptosis and its role in human disease

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12 December 2020

Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases

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12 December 2020

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays

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12 December 2020

Induction of apoptosis in HeLa cells by trans-activation-deficient p53

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12 December 2020

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle.

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12 December 2020

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

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12 December 2020

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)

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12 December 2020

Bcl2 is the guardian of microtubule integrity

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12 December 2020

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death

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12 December 2020

p53: puzzle and paradigm

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12 December 2020

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

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12 December 2020

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

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12 December 2020

Cell cycle and apoptosis: common pathways to life and death.

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12 December 2020

Identification and characterization of a new member of the TNF family that induces apoptosis

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12 December 2020

Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family

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12 December 2020

FLICE Induced Apoptosis in a Cell-free System

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12 December 2020

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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12 December 2020

Inactivation of Bcl-2 by phosphorylation

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12 December 2020

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

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12 December 2020

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis

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12 December 2020

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1 reference

12 December 2020

Fluctuations and ultrastructural localization of oncoproteins and cell cycle regulatory proteins during growth and apoptosis of synchronized AGF cells

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12 December 2020

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

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12 December 2020

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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12 December 2020

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

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12 December 2020

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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12 December 2020

Apoptosis and disease: regulation and clinical relevance of programmed cell death

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12 December 2020

Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts

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12 December 2020

Apoptosis: molecular regulation of cell death

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12 December 2020

The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle

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12 December 2020

Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2

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12 December 2020

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

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12 December 2020

Mitochondrial control of apoptosis

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12 December 2020

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

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12 December 2020

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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12 December 2020

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.

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12 December 2020

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

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12 December 2020

Functions of ceramide in coordinating cellular responses to stress

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12 December 2020

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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12 December 2020

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

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12 December 2020

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family

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12 December 2020

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

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12 December 2020

p53 and treatment of bladder cancer

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12 December 2020

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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12 December 2020

Programmed cell death: from development to disease

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12 December 2020

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12 December 2020

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

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12 December 2020

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

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12 December 2020

Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases

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12 December 2020

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme

1 reference

12 December 2020

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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12 December 2020

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1023/A:1012159208559

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7 October 2017

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