(Q41845349)

13 October 2017

Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid (English)

1 reference

Mycobacterium tuberculosis

13 October 2017

0 references

0 references

1

1 reference

13 October 2017

Gulcin Gulten

3

0 references

Thomas R Ioerger

8

object named as

Thomas R Ioerger

1 reference

13 October 2017

Paras Jain

2

1 reference

13 October 2017

Zhen Liu

4

1 reference

13 October 2017

Yicheng Feng

5

1 reference

13 October 2017

Krishna Ganesula

6

1 reference

13 October 2017

Alifiya S Motiwala

7

1 reference

13 October 2017

David Alland

9

1 reference

13 October 2017

Catherine Vilchèze

10

1 reference

13 October 2017

William R Jacobs

11

1 reference

13 October 2017

James C Sacchettini

12

1 reference

13 October 2017

language of work or name

English

0 references

publication date

21 June 2010

1 reference

Antimicrobial Agents and Chemotherapy

13 October 2017

1 reference

13 October 2017

54

1 reference

13 October 2017

3776-3782

1 reference

13 October 2017

9

1 reference

Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Dihydrofolate reductase as a target for chemotherapy in parasites

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Mechanism of thioamide drug action against tuberculosis and leprosy

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Mechanisms of action of isoniazid

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Multicenter study of MTT and resazurin assays for testing susceptibility to first-line anti-tuberculosis drugs.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

DNA and RNA synthesis: antifolates

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Genetic requirements for mycobacterial survival during infection

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Genetics and pulmonary medicine. 5. Genetics of drug resistant tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Effects of isoniazid on mycolic acid synthesis in Mycobacterium tuberculosis and on its cell envelope

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Control Mechanisms for Fatty Acid Synthesis in Mycobacterium Smegmatis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Chemotherapy of experimental tuberculosis. V. Isonicotinic acid hydrazide (nydrazid) and related compounds.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935018

Genetic Manipulation of Mycobacterium tuberculosis

18 August 2018

1 reference

12 December 2020

Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of inha inhibitor

1 reference

12 December 2020

Hydrogen Peroxide-Mediated Isoniazid Activation Catalyzed byMycobacterium tuberculosisCatalase−Peroxidase (KatG) and Its S315T Mutant†,‡

1 reference

12 December 2020

Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid

1 reference

12 December 2020

Identifiers

DOI

10.1128/AAC.00453-10

1 reference

13 October 2017

1 reference

13 October 2017

1 reference