(Q41861528)

English

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors

scientific article published on 9 January 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

0 references

allosteric inhibitor

1 reference

based on heuristic

inferred from title

Anita Niedziela-Majka

3

object named as

Anita Niedziela-Majka

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Magdeleine Hung

9

object named as

Magdeleine Hung

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

14

object named as

Roman Sakowicz

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

10

object named as

Martijn Fenaux

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

6

object named as

Elaine Kan

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

13

object named as

Uli Schmitz

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Leanna Lagpacan

7

object named as

Leanna Lagpacan

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

11

object named as

Todd Appleby

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

author name string

Sarah E Boyce

1

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Neeraj Tirunagari

2

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Jason Perry

4

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Melanie Wong

5

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Ona Barauskas

8

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Europe PubMed Central

PMC publication ID

13 October 2017

William J Watkins

12

1 reference

Europe PubMed Central

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13 October 2017

language of work or name

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publication date

9 January 2014

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Europe PubMed Central

PMC publication ID

13 October 2017

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

9

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

1

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

e84808

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

copyright license

Creative Commons Attribution 4.0 International

9 January 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.

1 reference

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1 reference

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Hepatitis C virus RNA replication

1 reference

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1 reference

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1 reference

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Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase

1 reference

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Differential scanning calorimetry as a tool for protein folding and stability

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Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase

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Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

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Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex

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1 reference

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Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

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Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions.

1 reference

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5 June 2018

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

1 reference

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5 June 2018

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

1 reference

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Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

1 reference

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Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor

1 reference

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A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

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Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

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Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor

1 reference

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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

1 reference

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Global epidemiology of hepatitis C virus infection

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1 reference

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1 reference

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18 August 2018

Identifiers

10.1371/JOURNAL.PONE.0084808

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

2014PLoSO...984808B

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

ResearchGate publication ID

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