(Q41865665)

English

Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 io

scientific article published on June 1994

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 io (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

author name string

Thomas MP

1

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Topham CM

2

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Kowlessur D

3

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Mellor GW

4

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Thomas EW

5

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Whitford D

6

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Brocklehurst K

7

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

language of work or name

0 references

publication date

1 June 1994

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

300 ( Pt 3)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

805-820

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Appendix: Analysis of pH-dependent kinetics in up to four reactive hydronic states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Catalytic-site characteristics of the porcine calpain II 80 kDa/18 kDa heterodimer revealed by selective reaction of its essential thiol group with two-hydronic-state time-dependent inhibitors: evidence for a catalytic site Cys/His interactive syste

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Ionization characteristics of the Cys-25/His-159 interactive system and of the modulatory group of papain: resolution of ambiguity by electronic perturbation of the quasi-2-mercaptopyridine leaving group in a new pyrimidyl disulphide reactivity prob

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

A sound basis for pH-dependent kinetic studies on enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Isolation of highly active papaya peptidases A and B from commercial chymopapain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Structure of papain refined at 1.65 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Chymopapain. Chromatographic purification and immunological characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

'Chymopapain S' is chymopapain A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Effects of conformational selectivity and of overlapping kinetically influential ionizations on the characteristics of pH-dependent enzyme kinetics. Implications of free-enzyme pKa variability in reactions of papain for its catalytic mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Chymopapain C, an immunosuppressive protease. I. Partial purification and characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Covalent chromatography. Preparation of fully active papain from dried papaya latex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Shapes of curves of pH-dependence of reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase omega

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

The electrostatic fields in the active-site clefts of actinidin and papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase omega

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Structural and electrostatic differences between actinidin and papain account for differences in activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe stu

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Nucleotide sequence of actinidin, a kiwi fruit protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Papaya proteinase IV amino acid sequence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Selective cleavage of glycyl bonds by papaya proteinase IV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

A general kinetic equation for multihydronic state reactions and rapid procedures for parameter evaluation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Preliminary crystallographic data for protease omega

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

An assessment of COMPOSER: a rule-based approach to modelling protein structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by t

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Interactions of papaya proteinase IV with inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Towards an understanding of the arginine-aspartate interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Crystal structure of an actinidin-E-64 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

The amino acid sequence of the tryptic peptides from actinidin, a proteolytic enzyme from the fruit of Actinidia chinensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Isolation and characterization of papaya peptidase A from commercial chymopapain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

A reporter group delivery system with both absolute and selective specificity for thiol groups and an improved fluorescent probe containing the 7-nitrobenzo-2-oxa-1,3-diazole moiety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

5 June 2018

Clarification of the pH-dependent kinetic behaviour of papain by using reactivity probes and analysis of alkylation and catalysed acylation reactions in terms of multihydronic state models: implications for electrostatics calculations and interpreta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

18 August 2018

Evidence for a close similarity in the catalytic sites of papain and ficin in near-neutral media despite differences in acidic and alkaline media. Kinetics of the reactions of papain and ficin with chloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

18 August 2018

A re-evaluation of the nomenclature of the cysteine proteinases of Carica papaya and a rational basis for their identification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

18 August 2018

Cloning and sequencing of papain-encoding cDNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

18 August 2018

Investigation of mechanistic consequences of natural structural variation within the cysteine proteinases by knowledge-based modelling and kinetic methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

18 August 2018

Three-dimensional structure and thiol reactivity characteristics of chymopapain M (papaya proteinase IV)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138238

3 November 2018

Ficin: a cysteine proteinase with binding site-catalytic site signalling characteristics intermediate between those of papain and actinidin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetically influential ionizations of chymopapain M

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-terminal homology in three cysteinyl proteases from Papaya Latex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The thiol proteinases from the latex of Carica papaya L. IV. Proteolytic specificities of chymopapain and papaya proteinase omega determined by digestion of alpha-globin chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Trypsin-Catalyzed Hydrolysis of the p-Nitrophenyl, Methyl, and Benzyl Esters of α-N-Benzyloxycarbonyl-L-lysine1

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for multiple reactive forms of papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chymopapain. IV. The chromatographic fractionation of partially purified chymopapain and the characterization of crystalline chymopapain B

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of actinidin, after refinement at 1.7 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amino acid sequence of a novel inhibitor of cathepsin D from potato

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Preparation and Some Properties of Bromelain Covalently Attached to O-(Carboxymethyl)-Cellulose

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Covalent chromatography by thiol-disulfide interchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis of papaya proteinase omega

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A purification and some properties of two proteases from papaya latex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The thiol proteinases from the latex of Carica papaya L. I. Fractionation, purification and preliminary characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

24 Two-protonic-state electrophiles as probes of enzyme mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The preparation and properties of two new chromogenic substrates of trypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8010964

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3000805

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

ResearchGate publication ID

0 references

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