(Q41883243)

English

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).

scientific article published on 17 May 2011

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scholarly article

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Europe PubMed Central

PMC publication ID

13 October 2017

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs). (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

G protein-coupled receptor

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transmembrane protein

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Catherine Louise Worth

7

object named as

Catherine L Worth

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

author name string

Gunnar Kleinau

1

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Europe PubMed Central

PMC publication ID

13 October 2017

Inna Hoyer

2

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Europe PubMed Central

PMC publication ID

13 October 2017

Annika Kreuchwig

3

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Ann-Karin Haas

4

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Claudia Rutz

5

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Jens Furkert

6

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Gerd Krause

8

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Ralf Schülein

9

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Europe PubMed Central

PMC publication ID

13 October 2017

language of work or name

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publication date

17 May 2011

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Europe PubMed Central

PMC publication ID

13 October 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

13 October 2017

286

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Europe PubMed Central

PMC publication ID

13 October 2017

29

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Europe PubMed Central

PMC publication ID

13 October 2017

25859-25871

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

1 reference

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Current standards, variations, and pitfalls for the determination of constitutive TSHR activity in vitro

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Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients

1 reference

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An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors

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Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

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Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.

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Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.

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Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor

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A G protein-coupled receptor at work: the rhodopsin model.

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Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors

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Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models

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Multiple switches in G protein-coupled receptor activation

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Structural waters define a functional channel mediating activation of the GPCR, rhodopsin.

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Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

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Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface

1 reference

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5 June 2018

G-protein-coupled receptor structures were not built in a day

1 reference

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5 June 2018

Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas.

1 reference

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5 June 2018

The structure and function of G-protein-coupled receptors

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5 June 2018

Comparative analysis of GPCR crystal structures

1 reference

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5 June 2018

Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization

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Discovery of new GPCR biology: one receptor structure at a time

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Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.

1 reference

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Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.

1 reference

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5 June 2018

Conformational changes involved in G-protein-coupled-receptor activation

1 reference

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

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Crystal structure of opsin in its G-protein-interacting conformation

1 reference

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5 June 2018

Atomistic insights into rhodopsin activation from a dynamic model

1 reference

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Structure of a beta1-adrenergic G-protein-coupled receptor

1 reference

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Crystal structure of the ligand-free G-protein-coupled receptor opsin

1 reference

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Crystal structure of squid rhodopsin

1 reference

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Crystal Structure of Squid Rhodopsin with Intracellularly Extended Cytoplasmic Region

1 reference

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New G-protein-coupled receptor crystal structures: insights and limitations

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Heterotrimeric G protein activation by G-protein-coupled receptors

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

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Crystal Structure of a Thermally Stable Rhodopsin Mutant

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Conformational complexity of G-protein-coupled receptors

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Technology Insight: modern methods to monitor protein-protein interactions reveal functional TSH receptor oligomerization

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Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource

1 reference

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Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

1 reference

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Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway

1 reference

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5 June 2018

Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.

1 reference

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Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences

1 reference

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Molecular mechanism of 7TM receptor activation--a global toggle switch model

1 reference

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5 June 2018

Repulsive separation of the cytoplasmic ends of transmembrane helices 3 and 6 is linked to receptor activation in a novel thyrotropin receptor mutant (M626I).

1 reference

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Computational modeling approaches to structure-function analysis of G protein-coupled receptors

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TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5.

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Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules

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A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.

1 reference

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The structural basis of G-protein-coupled receptor function and dysfunction in human diseases

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Crystal structure of rhodopsin: A G protein-coupled receptor

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A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling.

1 reference

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Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

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Assays of cyclic nucleotides. A review of current techniques

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Mild congenital primary hypothyroidism in a Turkish family caused by a homozygous missense thyrotropin receptor (TSHR) gene mutation (A593 V).

1 reference

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18 August 2018

An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

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Functional significance of the thyrotropin receptor germline polymorphism D727E.

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A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation

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Requirement of specific intrahelical interactions for stabilizing the inactive conformation of glycoprotein hormone receptors.

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The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies

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Signal transduction: The rhodopsin story continued

1 reference

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Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor

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Multiple mechanisms of receptor-G protein signaling specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21586576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of the thyrotropin receptor by mutating CYS-636 in the sixth transmembrane segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21586576

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based on heuristic

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Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma

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https://pubmed.ncbi.nlm.nih.gov/21586576

12 December 2020

based on heuristic

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Identification and functional analysis of novel inactivating thyrotropin receptor mutations in patients with thyrotropin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21586576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/21586576

12 December 2020

based on heuristic

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Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/21586576

12 December 2020

based on heuristic

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A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R

1 reference

https://pubmed.ncbi.nlm.nih.gov/21586576

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based on heuristic

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Identifiers

10.1074/JBC.M110.196980

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

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