(Q42088517)

16 October 2017

Molecular mechanisms of functional rescue mediated by P53 tumor suppressor mutations (English)

1 reference

16 October 2017

Ray Luo

8

0 references

author name string

Yu-Hong Tan

1

1 reference

16 October 2017

Y Morris Chen

2

1 reference

16 October 2017

Xiang Ye

3

1 reference

16 October 2017

Qiang Lu

4

1 reference

16 October 2017

Vira Tretyachenko-Ladokhina

5

1 reference

16 October 2017

Wei Yang

6

1 reference

16 October 2017

Donald F Senear

7

1 reference

16 October 2017

1 September 2009

1 reference

16 October 2017

Biophysical Chemistry

1 reference

16 October 2017

145

1 reference

16 October 2017

1

1 reference

16 October 2017

37-44

1 reference

p53-Induced DNA bending: the interplay between p53-DNA and p53-p53 interactions

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 Å resolution

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Stability of the core domain of p53: insights from computer simulations

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Molecular dynamics simulations of p53 DNA-binding domain

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Structure of the human p53 core domain in the absence of DNA

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Force field influences in beta-hairpin folding simulations

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

A global suppressor motif for p53 cancer mutants

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Rescuing the function of mutant p53.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Thermodynamic stability of wild-type and mutant p53 core domain

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Determination and analysis of urea and guanidine hydrochloride denaturation curves

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Essential energy space random walk via energy space metadynamics method to accelerate molecular dynamics simulations.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Structural basis for p53 binding-induced DNA bending

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Kinetic partitioning during folding of the p53 DNA binding domain

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

The IARC TP53 database: new online mutation analysis and recommendations to users

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Kinetic Instability of p53 Core Domain Mutants

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794655

Dimerization of the core domain of the p53 family: a computational study

1 December 2018

1 reference

12 December 2020

Genetic strategies in Saccharomyces cerevisiae to study human tumor suppressor genes

1 reference

12 December 2020

Structure-based rescue of common tumor-derived p53 mutants

1 reference

12 December 2020

High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds

1 reference

12 December 2020

10.1016/J.BPC.2009.08.008

Identifiers

DOI

1 reference

16 October 2017

1 reference

16 October 2017

PubMed publication ID

19748724

1 reference