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Advances in Overcoming Immune Responses following Hemophilia Gene Therapy.
scientific article published on December 2011
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
title
Advances in Overcoming Immune Responses following Hemophilia Gene Therapy
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
main subject
gene therapy
0 references
hemophilia
0 references
author name string
Carol H Miao
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
publication date
1 December 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
published in
Journal of genetic syndromes & gene therapy
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
volume
S1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
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A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo
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Gene therapy for hemophilia B: AAV-mediated transfer of the gene for coagulation factor IX to human muscle.
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26 October 2017
Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
26 October 2017
Genetic induction of immune tolerance to human clotting factor VIII in a mouse model for hemophilia A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
26 October 2017
Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
26 October 2017
In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
26 October 2017
Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
26 October 2017
A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
29 May 2018
Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
29 May 2018
Preventing restimulation of memory B cells in hemophilia A: a potential new strategy for the treatment of antibody-dependent immune disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
29 May 2018
Generation and characterization of E1/E2a/E3/E4-deficient adenoviral vectors encoding human factor VIII.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
29 May 2018
Implantation of autologous skin fibroblast genetically modified to secrete clotting factor IX partially corrects the hemorrhagic tendencies in two hemophilia B patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
29 May 2018
Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
29 May 2018
Stage I clinical trial of gene therapy for hemophilia B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
29 May 2018
B-cell-delivered gene therapy induces functional T regulatory cells and leads to a loss of antigen-specific effector cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Correction of murine hemophilia A and immunological differences of factor VIII variants delivered by helper-dependent adenoviral vectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Hematopoietic stem cells encoding porcine factor VIII induce pro-coagulant activity in hemophilia A mice with pre-existing factor VIII immunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C2 domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
High-Level Factor VIII Gene ExpressionIn VivoAchieved by Nonviral Liver-Specific Gene Therapy Vectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Neonatal gene transfer with a retroviral vector results in tolerance to human factor IX in mice and dogs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Complete and sustained phenotypic correction of hemophilia B in mice following hepatic gene transfer of a high-expressing human factor IX plasmid
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Neonatal or hepatocyte growth factor-potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Production of human clotting Factor IX without toxicity in mice after vascular delivery of a lentiviral vector
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Risk and prevention of anti-factor IX formation in AAV-mediated gene transfer in the context of a large deletion of F9.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Muscle-directed gene transfer and transient immune suppression result in sustained partial correction of canine hemophilia B caused by a null mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Nonviral transfer of the gene encoding coagulation factor VIII in patients with severe hemophilia A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Role of CD154 in the secondary immune response: the reduction of pre-existing splenic germinal centers and anti-factor VIII inhibitor titer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Partial correction of murine hemophilia A with neo-antigenic murine factor VIII.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
17 August 2018
In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379895
retrieved
3 November 2018
Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22737594
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22737594
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22737594
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
PMC publication ID
3379895
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
PubMed publication ID
22737594
1 reference
stated in
Europe PubMed Central
PMC publication ID
3379895
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22737594%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
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