(Q42362086)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

title

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

main subject

Cyclic GMP-AMP synthase

1 reference

2',3'-cyclic GMP-AMP synthase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Justin Hall

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

15

Douglas Golenbock

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

author name string

Amy Brault

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Fabien Vincent

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Shawn Weng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Hong Wang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Darren Dumlao

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Ann Aulabaugh

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Dikran Aivazian

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Dana Castro

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Ming Chen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Jeffrey Culp

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Ken Dower

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Joseph Gardner

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Steven Hawrylik

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

David Hepworth

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Mark Horn

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Lyn Jones

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Peter Jones

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Eicke Latz

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Jing Li

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Lih-Ling Lin

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Wen Lin

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

David Lin

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Frank Lovering

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Nootaree Niljanskul

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Ryan Nistler

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Betsy Pierce

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Olga Plotnikova

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Daniel Schmitt

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Suman Shanker

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

James Smith

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

William Snyder

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Timothy Subashi

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

John Trujillo

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Edyta Tyminski

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Guoxing Wang

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Jimson Wong

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Bruce Lefker

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Leslie Dakin

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Karen Leach

41

1 reference

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30 March 2020

language of work or name

English

0 references

publication date

21 September 2017

1 reference

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30 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

page(s)

e0184843

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

30 March 2020

copyright license

start time

21 September 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

The Type I Interferonopathies.

29 May 2018

1 reference

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cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Discriminating self from non-self in nucleic acid sensing

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Translating nucleic acid-sensing pathways into therapies

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Aicardi-Goutières syndrome and the type I interferonopathies

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

PRRs are watching you: Localization of innate sensing and signaling regulators

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Activated STING in a vascular and pulmonary syndrome

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

The interferon response to intracellular DNA: why so many receptors?

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

The cGAS-STING pathway for DNA sensing

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Structural mechanism of cytosolic DNA sensing by cGAS

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

STING and the innate immune response to nucleic acids in the cytosol

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Development of a rule-based method for the assessment of protein druggability

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Identifying and characterizing binding sites and assessing druggability

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Trex1 prevents cell-intrinsic initiation of autoimmunity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Cytosolic DNA Sensing: The Field Narrows

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Long-range 1H-15N J couplings providing a method for direct studies of the structure and azide-tetrazole equilibrium in a series of azido-1,2,4-triazines and azidopyrimidines.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Structure-based maximal affinity model predicts small-molecule druggability.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5608272

Type I interferonopathies: a novel set of inborn errors of immunity

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0184843

10.1371/JOURNAL.PONE.0184843

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28934246%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference