(Q42383180)

English

The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein

scientific article published on 19 August 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein (English)

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

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chronic lymphocytic leukemia

1 reference

based on heuristic

inferred from title

Stephan Stilgenbauer

9

object named as

Stephan Stilgenbauer

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author name string

Claudia Walliser

1

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Elisabeth Hermkes

2

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Anja Schade

3

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Sebastian Wiese

4

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Julia Deinzer

5

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Marc Zapatka

6

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Laurent Désiré

7

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Daniel Mertens

8

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Peter Gierschik

10

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Europe PubMed Central

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28 October 2017

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publication date

19 August 2016

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Europe PubMed Central

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28 October 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

28 October 2017

291

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Europe PubMed Central

PMC publication ID

28 October 2017

42

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

22136-22148

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

1 reference

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Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

1 reference

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JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemia

1 reference

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28 May 2018

Ibrutinib-A double-edge sword in cancer and autoimmune disorders.

1 reference

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28 May 2018

Advances in first-line treatment of chronic lymphocytic leukemia: current recommendations on management and first-line treatment by the German CLL Study Group (GCLLSG).

1 reference

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28 May 2018

FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia

1 reference

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28 May 2018

Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma.

1 reference

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28 May 2018

Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment

1 reference

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28 May 2018

Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia

1 reference

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Ibrutinib for the treatment of Waldenström macroglobulinemia

1 reference

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1 reference

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28 May 2018

Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation

1 reference

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28 May 2018

Rac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling.

1 reference

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28 May 2018

Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)

1 reference

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28 May 2018

Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

1 reference

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28 May 2018

B lymphocyte antigen receptor signaling: initiation, amplification, and regulation

1 reference

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Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

1 reference

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28 May 2018

Mammalian phospholipase C.

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28 May 2018

Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

1 reference

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28 May 2018

A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency

1 reference

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28 May 2018

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

1 reference

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28 May 2018

Integration of B cell responses through Toll-like receptors and antigen receptors

1 reference

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AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments

1 reference

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28 May 2018

Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2.

1 reference

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28 May 2018

Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-β2.

1 reference

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28 May 2018

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

1 reference

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28 May 2018

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

1 reference

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Autoinhibition and adapter function of Syk.

1 reference

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28 May 2018

Characterization of phospholipase C gamma enzymes with gain-of-function mutations

1 reference

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Identification of the large-conductance background K+ channel in mouse B cells as TREK-2.

1 reference

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

1 reference

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28 May 2018

Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation

1 reference

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Rac Regulates Its Effector Phospholipase C 2 through Interaction with a Split Pleckstrin Homology Domain

1 reference

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General and Versatile Autoinhibition of PLC Isozymes

1 reference

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Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

1 reference

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1 reference

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Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

1 reference

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1 reference

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Regulation of phospholipase C-gamma2 networks in B lymphocytes

1 reference

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28 May 2018

Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases

1 reference

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RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

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B cell signaling and tumorigenesis

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Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

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28 May 2018

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

1 reference

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28 May 2018

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1 reference

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12 December 2020

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10.1074/JBC.M116.746842

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

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