(Q42468494)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10050879%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice (English)

1 reference

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11 November 2019

1 reference

5

1 reference

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11 November 2019

author name string

M Alkhalaf

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10050879%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

G Ganguli

2

1 reference

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11 November 2019

N Messaddeq

3

1 reference

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11 November 2019

M Le Meur

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10050879%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

language of work or name

English

0 references

publication date

1 February 1999

1 reference

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11 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10050879%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

volume

18

1 reference

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11 November 2019

issue

7

1 reference

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11 November 2019

page(s)

1419-1434

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1202448

11 November 2019

exact match

0 references

cites work

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

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Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.

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Multiple patterns of MDM-2 deregulation in human leukemias: implications in leukemogenesis and prognosis

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Regulation of gene expression in developing epidermal epithelia

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Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

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Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice

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Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

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TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

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MDM-2 protein is expressed in different layers of normal human skin

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The genetics of human skin diseases

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Amplification of MDM2 inhibits MyoD-mediated myogenesis

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

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Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis

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The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice

21 January 2018

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21 January 2018

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21 January 2018

The mdm2 proto-oncogene

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Tumor suppressors: a developing role for p53?

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p53; from inductive signal to cellular effect

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Mdm2 promotes the rapid degradation of p53

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Tumor spectrum analysis in p53-mutant mice

21 January 2018

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E2F as a regulator of keratinocyte proliferation: implications for skin tumor development

21 January 2018

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

21 January 2018

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Unusual cell specific expression of a major human cytomegalovirus immediate early gene promoter-lacZ hybrid gene in transgenic mouse embryos

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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MDM2--arbiter of p53's destruction

21 January 2018

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The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

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21 January 2018

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

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Analysis of p53 and mdm-2 expression in 18 patients with Sézary syndrome

21 January 2018

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21 January 2018

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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p53 and tumour viruses: catching the guardian off-guard

21 January 2018

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21 January 2018

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Delays in malignant tumor development in transgenic mice by forced epidermal keratin 10 expression in mouse skin carcinomas

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

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Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

21 January 2018

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Involvement of p53 in cell differentiation and development

21 January 2018

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7 January 2021

Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice

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7 January 2021

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

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7 January 2021

Abnormal expression of MDM-2 in breast carcinomas

1 reference

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7 January 2021

Tissue-specific and differentiation-appropriate expression of the human involucrin gene in transgenic mice: an abnormal epidermal phenotype

1 reference

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7 January 2021

The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status

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7 January 2021

Genetic skin diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Biologic structure and function: perspectives on morphologic approaches to the study of the granular layer keratinocyte

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7 January 2021

P53 gene alterations in human tumors: perspectives for cancer control.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

p53 and ATM: cell cycle, cell death, and cancer.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Apoptosis and cutaneous biology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Papillomavirus infections--a major cause of human cancers

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10050879%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 November 2019

1045798606

0 references

1 reference