Wikidata

(Q425201)

English

BCL2 apoptosis regulator

mammalian protein found in Homo sapiens

  • protein phosphatase 1, regulatory subunit 50
  • B-cell CLL/lymphoma 2
  • apoptosis regulator Bcl-2
  • Bcl-2
  • BCL2
  • PPP1R50
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
63 references
retrieved
8 April 2019
stated in
PUMA induces the rapid apoptosis of colorectal cancer cells
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
BAG-1 modulates the chaperone activity of Hsp70/Hsc70.
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-G, a novel pro-apoptotic member of the Bcl-2 family
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Control of autophagic cell death by caspase-10 in multiple myeloma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
The IKK complex contributes to the induction of autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
retrieved
8 April 2019
stated in
The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IPI
cell component
biological process
negative regulation of apoptotic process
determination method or standard
IDA
IEA
IGI
IMP
TAS
18 references
retrieved
16 July 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
TAS
retrieved
16 July 2018
stated in
BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IMP
retrieved
16 July 2018
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IMP
retrieved
16 July 2018
stated in
Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IMP
retrieved
16 July 2018
stated in
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IGI
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IEA
retrieved
16 July 2018
stated in
Regulation of acidification and apoptosis by SHP-1 and Bcl-2
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
Proapoptotic BAX and BAK control multiple initiator caspases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
Inhibition of Bax channel-forming activity by Bcl-2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
16 July 2018
stated in
Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10415&geneProductId=UniProtKB:P10415
determination method or standard
IDA
negative regulation of apoptotic process
determination method or standard
IBA
IDA
IEA
IGI
IMP
TAS
20 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
TAS
retrieved
8 April 2019
stated in
BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IMP
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IMP
retrieved
8 April 2019
stated in
Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IMP
retrieved
8 April 2019
stated in
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IGI
retrieved
8 April 2019
stated in
miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IEA
retrieved
8 April 2019
stated in
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Regulation of acidification and apoptosis by SHP-1 and Bcl-2
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
GOA
curator
UniProt
UniProt protein ID
P10415
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Proapoptotic BAX and BAK control multiple initiator caspases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Inhibition of Bax channel-forming activity by Bcl-2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10415
determination method or standard
IBA

Identifiers

Microsoft Academic ID
2909467883
0 references
2910218159
0 references
PDB structure ID
 
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