(Q42594325)

English

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

scientific article published on 5 October 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes (English)

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

1 reference

based on heuristic

inferred from title

David K. Finlay

1

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Doreen Cantrell

7

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

6

object named as

Hergen Spits

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

author name string

Linda V Sinclair

2

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Carmen Feijoo

3

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Caryll M Waugh

4

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Thijs J Hagenbeek

5

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

language of work or name

0 references

publication date

5 October 2009

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

206

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

11

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

2441-2454

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

PI3K pathway alterations in cancer: variations on a theme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

miRiad roles for the miR-17-92 cluster in development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

A brief introduction to FOXOlogy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Portrait of PTEN: messages from mutant mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Finding a way out: lymphocyte egress from lymphoid organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Deletion of PKBalpha/Akt1 affects thymic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

The RhoA transcriptional program in pre-T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Notch-induced T cell development requires phosphoinositide-dependent kinase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Kruppel-like factor 2 regulates thymocyte and T-cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

T-cell homing specificity and plasticity: new concepts and future challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Akt-dependent transformation: there is more to growth than just surviving

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

28 May 2018

FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

Phosphatidylinositol 3-kinase regulates thymic exit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768858

16 August 2018

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20090219

21 January 2018

Differential regulation of T-cell growth by IL-2 and IL-15

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonates support "homeostatic" proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for CD44 in activated T cell extravasation into an inflammatory site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Rho at different stages of thymocyte development gives different perspectives on Rho function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19808258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20090219

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

ResearchGate publication ID

0 references

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