(Q42737591)

English

Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer m

scientific article published on April 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer m (English)

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

Alzheimer's disease

0 references

Sebastian Jimenez

object named as

Sebastian Jimenez

1

0 references

Manuel Torres Canalejo

object named as

Manuel Torres

2

0 references

Laura Trujillo-Estrada

object named as

Laura Trujillo-Estrada

6

0 references

object named as

Marisa Vizuete

3

0 references

object named as

Diego Ruano

9

0 references

Antonia Gutierrez

object named as

Antonia Gutierrez

10

0 references

Javier Vitorica

object named as

Javier Vitorica

11

0 references

author name string

Raquel Sanchez-Varo

4

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

Elisabeth Sanchez-Mejias

5

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

Irene Carmona-Cuenca

7

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

Cristina Caballero

8

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

language of work or name

0 references

publication date

1 April 2011

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

286

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

21

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

18414-18425

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

1 reference

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Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration

1 reference

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27 May 2018

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

1 reference

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27 May 2018

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo

1 reference

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Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

1 reference

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27 May 2018

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

1 reference

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27 May 2018

Cholinergic system during the progression of Alzheimer's disease: therapeutic implications

1 reference

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

1 reference

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27 May 2018

Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor.

1 reference

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27 May 2018

Neurotrophins: from pathophysiology to treatment in Alzheimer's disease

1 reference

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27 May 2018

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

LTP inhibits LTD in the hippocampus via regulation of GSK3beta

1 reference

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27 May 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease

1 reference

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27 May 2018

The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

1 reference

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27 May 2018

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

1 reference

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27 May 2018

Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex

1 reference

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27 May 2018

Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance

1 reference

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27 May 2018

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Signaling by insulin-like growth factor 1 in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Function and regulation of CREB family transcription factors in the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

https://pubmed.ncbi.nlm.nih.gov/21460223

12 December 2020

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inferred from PubMed ID database lookup

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

beta-catenin is a target for the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits.

1 reference

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Neurotrophins and neuronal plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

27 May 2018

Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

16 August 2018

Beta-amyloid monomers are neuroprotective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

16 August 2018

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

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Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

16 August 2018

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

16 August 2018

Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

16 August 2018

Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

16 August 2018

Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.

1 reference

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16 August 2018

Monoclonal antibodies that target pathological assemblies of Abeta

1 reference

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Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection

1 reference

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Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

1 reference

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16 August 2018

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

1 reference

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Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease

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Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

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16 August 2018

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

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The coupling of a trkB tyrosine residue to LTP

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16 August 2018

Serum insulin-like growth factor I regulates brain amyloid-beta levels.

1 reference

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16 August 2018

Risk factors for Alzheimer's disease during aging. Impacts of glucose/energy metabolism

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16 August 2018

GSK3: an in-Toll-erant protein kinase?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099658

1 December 2018

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21460223

12 December 2020

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21460223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity in the allosteric interaction between the gamma-aminobutyric acid (GABA) binding site and three different benzodiazepine binding sites of the GABAA/benzodiazepine receptor complex in the rat nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21460223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.209718

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

6 November 2017

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