(Q42929194)

11 November 2017

title

Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers (English)

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11 November 2017

James C Whisstock

2

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author name string

James A Huntington

series ordinal

1

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11 November 2017

publication date

1 August 2010

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11 November 2017

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11 November 2017

volume

391

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11 November 2017

issue

8

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11 November 2017

page(s)

973-982

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Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

11 November 2017

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Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

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A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

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Divining the serpin inhibition mechanism: a suicide substrate 'springe'?

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Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

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Structure of a serpin-protease complex shows inhibition by deformation

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Bypassing the kinetic trap of serpin protein folding by loop extension

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Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation

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Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation

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Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex

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Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

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Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21)

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Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

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21 January 2018

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Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

21 January 2018

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Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

21 January 2018

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The structure of a Michaelis serpin-protease complex

21 January 2018

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A structural basis for loop C-sheet polymerization in serpins

21 January 2018

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Dimers initiate and propagate serine protease inhibitor polymerisation.

21 January 2018

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How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration

21 January 2018

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How small peptides block and reverse serpin polymerisation.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1515/BC.2010.085

1 reference

11 November 2017

1 reference