(Q43198294)

15 November 2017

An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production (English)

1 reference

15 November 2017

Yuan Tian

1

1 reference

15 November 2017

Bhramdeo Bassit

series ordinal

2

1 reference

15 November 2017

Deming Chau

series ordinal

3

1 reference

15 November 2017

Yue-Ming Li

series ordinal

4

1 reference

15 November 2017

10 January 2010

1 reference

Nature Structural & Molecular Biology

15 November 2017

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15 November 2017

17

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15 November 2017

2

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15 November 2017

151-158

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.1743

15 November 2017

0 references

cites work

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1 reference

The C-terminus of the beta protein is critical in amyloidogenesis

31 March 2020

1 reference

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

31 March 2020

1 reference

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

31 March 2020

1 reference

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

31 March 2020

1 reference

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

31 March 2020

1 reference

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

31 March 2020

1 reference

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

31 March 2020

1 reference

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

31 March 2020

1 reference

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

31 March 2020

1 reference

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

31 March 2020

1 reference

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

31 March 2020

1 reference

Nicastrin functions as a gamma-secretase-substrate receptor

31 March 2020

1 reference

Alzheimer's disease: genes, proteins, and therapy

31 March 2020

1 reference

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

31 March 2020

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

31 March 2020

1 reference

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

31 March 2020

1 reference

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

31 March 2020

1 reference

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

31 March 2020

1 reference

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

31 March 2020

1 reference

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

31 March 2020

1 reference

{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.

31 March 2020

1 reference

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

31 March 2020

1 reference

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

31 March 2020

1 reference

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

31 March 2020

1 reference

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

31 March 2020

1 reference

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

31 March 2020

1 reference

Amyloid-beta dynamics correlate with neurological status in the injured human brain

31 March 2020

1 reference

A novel substrate for analyzing Alzheimer's disease gamma-secretase

31 March 2020

1 reference

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

31 March 2020

1 reference

Mice lacking both presenilin genes exhibit early embryonic patterning defects

31 March 2020

1 reference

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

31 March 2020

1 reference

Benzophenone photophores in biochemistry.

31 March 2020

1 reference

Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors

31 March 2020

1 reference

Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors

31 March 2020

1 reference

Designed Helical Peptides Inhibit an Intramembrane Protease

31 March 2020

1 reference

Substrate-targeting gamma-secretase modulators

31 March 2020

1 reference

Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation

31 March 2020

1 reference

The partial retro-inverso modification: a road traveled together

31 March 2020

1 reference

Antigenic mimicry of natural L-peptides with retro-inverso-peptidomimetics

31 March 2020

1 reference

Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors

31 March 2020

1 reference

Use of a retroinverso p53 peptide as an inhibitor of MDM2

31 March 2020

1 reference

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

31 March 2020

1 reference

Exosite-driven substrate specificity and function in coagulation

31 March 2020

1 reference

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

31 March 2020

1 reference

Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease

31 March 2020

1 reference

(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor

31 March 2020

1 reference

Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

31 March 2020

1 reference

A cytoplasmic inhibitor of the JNK signal transduction pathway

31 March 2020

1 reference

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

31 March 2020

1 reference

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

31 March 2020

1 reference

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

31 March 2020

1 reference

Autoinhibitory domains: modular effectors of cellular regulation

31 March 2020

1 reference

Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX.

31 March 2020

1 reference

Mutations in APP have independent effects on Abeta and CTFgamma generation

31 March 2020

1 reference

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20062056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Peptides targeting protein kinases: strategies and implications

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20062056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20062056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1743

1 reference

15 November 2017

1 reference