(Q44003275)

English

Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease

scientific article published in January 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Alzheimer's disease

0 references

4

object named as

Mark P Mattson

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

author name string

Sic L Chan

1

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Ward A Pedersen

2

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Hiayan Zhu

3

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

publication date

1 January 2002

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

NeuroMolecular Medicine

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

55-67

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Multiple roles of mouse Numb in tuning developmental cell fates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arbiter of differentiation and death: Notch signaling meets apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch1 is required for the coordinate segmentation of somites

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of requirement for presenilin1 in Notch1 signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The function of PTB domain proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch signaling: cell fate control and signal integration in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 regulates neuronal differentiation during neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch and presenilin: a proteolytic mechanism emerges

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of neuronal survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse numb is an essential gene involved in cortical neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: protective effects of notch-1 on TCR-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neoplastic transformation by Notch requires nuclear localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin mutations and calcium signaling defects in the nervous and immune systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PTB domain: a new protein module implicated in signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12025816

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/NMM:1:1:55

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

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