(Q44023815)

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Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 November 2017

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Alzheimer's disease

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6

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Christian Haass

4

object named as

Christian Haass

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author name string

Steffen Leutz

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Barbara Steiner

2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Celio A Marques

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Walter E Müller

5

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

publication date

1 June 2002

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Journal of Molecular Neuroscience

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

189-201

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manganese-induced reactive oxygen species: comparison between Mn+2 and Mn+3

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The significance of the Swedish APP670/671 mutation for the development of Alzheimer's disease amyloidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation in neuronal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase 3 in HL-60 cells exposed to hydrogen peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive expression of the machinery for programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and glutamate receptor antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12059037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/JMN:18:3:189

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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