(Q44128354)

30 November 2017

title

In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study (English)

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30 November 2017

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Gary N Y Chan

1

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30 November 2017

Victor Saldivia

2

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30 November 2017

Yingbo Yang

3

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30 November 2017

Henrianna Pang

4

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30 November 2017

Inés de Lannoy

5

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30 November 2017

Reina Bendayan

6

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30 November 2017

language of work or name

English

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publication date

15 July 2013

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Journal of Neurochemistry

30 November 2017

published in

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30 November 2017

volume

127

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30 November 2017

issue

3

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30 November 2017

page(s)

342-352

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Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus

30 November 2017

cites work

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In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation

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Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier

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Functional expression and localization of P-glycoprotein at the blood brain barrier

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In situ localization of P-glycoprotein (ABCB1) in human and rat brain

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Cellular reactions to implantation of a microdialysis tube in the rat hippocampus

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Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells

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Methodological issues in microdialysis sampling for pharmacokinetic studies

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Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

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Drug interactions at the blood-brain barrier: fact or fantasy?

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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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Membrane transporters in drug development

21 January 2018

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Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations?

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HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells.

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

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Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

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Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentratio

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Efflux transporters in the blood-brain interfaces--in vitro and in vivo methods and correlations

21 January 2018

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CSF as a surrogate for assessing CNS exposure: an industrial perspective

21 January 2018

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Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid

21 January 2018

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Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues

21 January 2018

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Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier

21 January 2018

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Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies

21 January 2018

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Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.

21 January 2018

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Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats

21 January 2018

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Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures.

21 January 2018

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21 January 2018

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In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice

21 January 2018

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

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Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

21 January 2018

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21 January 2018

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Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate

21 January 2018

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Quinidine as an ABCB1 probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study

21 January 2018

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MDR1 gene expression in brain of patients with medically intractable epilepsy

21 January 2018

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Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.

21 January 2018

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The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.

21 January 2018

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Change in P-glycoprotein and caveolin protein expression in brain striatum capillaries in New Zealand obese mice with type 2 diabetes

21 January 2018

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Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia

21 January 2018

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Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.12344

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30 November 2017

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