(Q44193974)

30 November 2017

title

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons (English)

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amyotrophic lateral sclerosis

30 November 2017

main subject

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alpha,alpha-trehalose

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2

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30 November 2017

8

Brigitte van Zundert

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30 November 2017

Karen Castillo

1

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30 November 2017

Vicente Valenzuela

3

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30 November 2017

Fabiola Rojas

4

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30 November 2017

Soledad Matus

5

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30 November 2017

Gabriela Mercado

6

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30 November 2017

Felipe A Court

7

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30 November 2017

Claudio Hetz

9

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30 November 2017

language of work or name

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6 June 2013

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30 November 2017

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30 November 2017

volume

9

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30 November 2017

issue

9

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30 November 2017

page(s)

1308-1320

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

30 November 2017

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Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

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Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

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Lithium delays progression of amyotrophic lateral sclerosis

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Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

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Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

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Autophagy dysregulation in amyotrophic lateral sclerosis.

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

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Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

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mTOR signaling in growth control and disease

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Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

21 January 2018

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Chemical modulators of autophagy as biological probes and potential therapeutics

21 January 2018

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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

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Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

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Mutant superoxide dismutase 1 overexpression in NSC-34 cells: effect of trehalose on aggregation, TDP-43 localization and levels of co-expressed glycoproteins

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Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein

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Autophagy induction by trehalose counteracts cellular prion infection

21 January 2018

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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

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Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

21 January 2018

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Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

21 January 2018

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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

21 January 2018

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Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice

21 January 2018

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Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

21 January 2018

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IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

21 January 2018

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JNK regulates FoxO-dependent autophagy in neurons

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

21 January 2018

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Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

21 January 2018

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagy and the integrated stress response

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Control of autophagy as a therapy for neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Lithium lacks effect on survival in amyotrophic lateral sclerosis: a phase IIb randomised sequential trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Protein folding stress in neurodegenerative diseases: a glimpse into the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Axonal degeneration is mediated by the mitochondrial permeability transition pore.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

21 January 2018

Identifiers

DOI

10.4161/AUTO.25188

1 reference

30 November 2017

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